Understanding Blood Clots and Inflammation in Pulmonary Embolism
Molecular and morphometric imaging of coagulation and inflammation in pulmonary embolism pathogenesis
This research looks for better ways to understand and treat pulmonary embolism, a serious condition caused by blood clots in the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Masonic Medical Research Laboratory, INC NIH-funded |
| Lab location | 1 site (Utica, United States) |
| Project ID | NIH-11192923 on NIH RePORTER |
What this research studies
We want to find new ways to diagnose and treat pulmonary embolism, which happens when blood clots block blood flow in the lungs. Current treatments can have serious side effects like bleeding, so we need safer and more effective options. This work uses a special mouse model to create and study blood clots that are similar to those found in people. By watching how these clots develop and how the body reacts to them over time, we hope to learn more about how pulmonary embolism progresses. We will use advanced imaging techniques to see how different cells, like immune cells and platelets, are involved in the clot and the body's response.
Who could benefit from this research
Good fit: Patients who have experienced or are at risk for pulmonary embolism could ultimately benefit from the improved diagnostic and therapeutic strategies developed from this research.
Not a fit: Patients without pulmonary embolism or related clotting disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify patients at higher risk and develop safer, more effective treatments for pulmonary embolism.
How similar studies have performed: While current treatments exist, this approach uses a novel animal model and advanced imaging to gain a deeper understanding of PE progression, which is a new direction.
Where this research is happening
Utica, United States
- Masonic Medical Research Laboratory, INC — Utica, United States (Active)
Researchers
- Principal investigator: Kessinger, Chase William — Masonic Medical Research Laboratory, INC
- Study coordinator: Kessinger, Chase William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.