Understanding Blood Clots and Inflammation in Pulmonary Embolism
Official title: Molecular and morphometric imaging of coagulation and inflammation in pulmonary embolism pathogenesis
Funded at Masonic Medical Research Laboratory, INC · NIH-11192923 · Data updated 2026-11-12
This research looks for better ways to understand and treat pulmonary embolism, a serious condition caused by blood clots in the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Masonic Medical Research Laboratory, INC NIH-funded |
| Lab location | 1 site (Utica, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $723,192 |
| NIH project number | 5R01HL158816-02 |
| Project ID | NIH-11192923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have experienced or are at risk for pulmonary embolism could ultimately benefit from the improved diagnostic and therapeutic strategies developed from this research.
✕Less likely to help
Patients without pulmonary embolism or related clotting disorders would not directly benefit from this specific research.
What this research studies
We want to find new ways to diagnose and treat pulmonary embolism, which happens when blood clots block blood flow in the lungs. Current treatments can have serious side effects like bleeding, so we need safer and more effective options. This work uses a special mouse model to create and study blood clots that are similar to those found in people. By watching how these clots develop and how the body reacts to them over time, we hope to learn more about how pulmonary embolism progresses. We will use advanced imaging techniques to see how different cells, like immune cells and platelets, are involved in the clot and the body's response.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify patients at higher risk and develop safer, more effective treatments for pulmonary embolism.
How similar studies have gone: While current treatments exist, this approach uses a novel animal model and advanced imaging to gain a deeper understanding of PE progression, which is a new direction.
Where this research is happening
-
Masonic Medical Research Laboratory, INC
Utica, United States Active
Researchers
- Principal investigator: Kessinger, Chase William — Masonic Medical Research Laboratory, INC
- Study coordinator: Kessinger, Chase William
Related research
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This trial tests whether delivering clot-dissolving medication directly to the lungs via a catheter helps people with submassive pulmonary embolism feel better and function better, with fewer bleeding risks.
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This study tests whether removing clot with a targeted catheter approach helps people with submassive pulmonary embolism feel better and move more easily, compared with not using catheter therapy.
-
Molecular and imaging study of blood clots and inflammation in pulmonary embolism
A research project uses a mouse model to understand how blood clots and inflammatory cells affect pulmonary embolism and its outcomes, with the goal of better diagnosis and treatment for people with PE.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.