Outpatient pulmonary rehabilitation for patients after pulmonary embolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, parallel, randomized waitlist-controlled trial investigates the short-term benefits of outpatient pulmonary rehabilitation (PR) for patients recovering from acute pulmonary embolism. Participants will be randomly assigned to either an intervention group receiving 6 weeks of PR or a control group that will not receive immediate treatment. After the study period, the control group will also have the opportunity to undergo PR. The aim is to assess improvements in functional capacity and quality of life for those affected by post-PE syndrome.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Post-PE syndrome (except patients previously diagnosed with CTEPH) diagnosed by any of the following:

  * Post-PE functional impairment criteria
  * Post-PE Cardiac Impairment criteria
  * Chronic Thromboembolic Disease criteria
* Possibility of starting rehabilitation between 12 and 36 weeks after the initial event of PE

Exclusion Criteria:

* CTEPH diagnosis
* Chronic pulmonary diseases: COPD, interstitial lung diseases, asthma (only patients with severe asthma defined as a FEV1 ≤ 80% will be excluded), a statement on COVID-19 was amended due to the pandemic #
* Active cancer
* Pregnancy
* Myocardial infarction or cardiac surgery one year prior to inclusion
* Congenital heart disease, congestive heart failure
* History of stroke
* Any previous inpatient or outpatient PR

Additional criteria that are absolute contraindications for pulmonary rehabilitation

* Acute and decompensated disease states with severe functional restrictions of various organ systems (e.g. heart, kidney and liver insufficiency, unstable angina pectoris, hemodynamically unstable arrhythmias, acute spinal cord injury, untreated hormonal disorders, acute psychological disorders)
* open tuberculosis
* active infectious diseases and acute inflammatory processes
* Stressful and time-consuming therapy that significantly impair the ability to rehabilitate (e.g. chemotherapy or radiation therapy after malignancy)
* Participants who are not sufficiently resilient due to physical or mental impairment and / or cannot be mobilized and therefore cannot actively use the rehabilitation facility
* lack of motivation for therapy
* massive incontinence
* drugs and alcohol addiction

Where it's running

• Therme Wien Med
  Vienna, Austria Recruiting

Study contacts

• Study coordinator: Stephan Nopp, Dr.
• Email: stephan.nopp@meduniwien.ac.at
• Phone: +43 40400 44170

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TRiP-cast score test in adults with acute lower-limb injuries requiring immobilization

  This study tests whether the TRiP(cast) score can predict risk of blood clots in adults with acute lower-limb injuries treated as outpatients.

  Recruiting University of Monastir · Monastir · NCT07863115

• Prognostic value of the 2026 AHA/ACC PE classification in ED patients with acute PE

  This study tests whether the 2026 AHA/ACC five-category PE classification helps predict 30-day major adverse pulmonary embolism events in adults with acute PE presenting to the ED.

  Recruiting Marmara University Pendik Training and Research Hospital · Istanbul · NCT07805616

• Right heart dysfunction in acute pulmonary embolism: can echocardiography help predict risk

  This study tests whether transthoracic echocardiography can identify right ventricular dysfunction in adults with acute pulmonary embolism to help gauge risk.

  Recruiting Sohag University · Sohag and 1 other locations · NCT07647497

• Aspiration thrombectomy with the Symphony or Prodigy devices

  This project will try the Symphony and Prodigy aspiration thrombectomy devices to remove arterial, venous, or pulmonary blood clots in adults.

  Recruiting at 13 sites Imperative Care, Inc. · Huntsville, Alabama and 12 other locations · NCT07350499

• PERC and YEARS approaches for diagnosing pulmonary embolism in the emergency department.

  This project will test whether using the PERC score and the YEARS algorithm helps emergency doctors decide which adults need D-dimer blood tests or chest CT scans to diagnose pulmonary embolism.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07313501

• Reperfusion options for acute pulmonary embolism

  This project will try catheter-directed interventions or systemic thrombolysis in adults with acute pulmonary embolism to see which approach leads to better outcomes.

  Recruiting at 12 sites Sahlgrenska University Hospital · Aarhus and 12 other locations · NCT07003646

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.