Improving quality of life with pulmonary rehabilitation after pulmonary embolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of pulmonary rehabilitation (PR) on patients who have experienced a pulmonary embolism (PE) and continue to suffer from dyspnea and reduced quality of life despite anticoagulation treatment. The intervention involves a structured PR program aimed at alleviating symptoms and enhancing overall well-being. Patients eligible for the study are those aged 18 and older who have been treated with anticoagulants for a specified duration and meet certain quality of life criteria. The study aims to provide evidence for the inclusion of PR in the therapeutic management of PE.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Patient treated with at least 3 months and up to 8 months of anticoagulation for symptomatic EP diagnosed according the ESC and ACCP guidelines.
* Patients who have a PembQol score ≥ 10% and whose total scores for the subgroups Q7+8 (dyspnea) and Q4 (impact of daily life) are ≥ 10%.

Exclusion Criteria:

* Presence of CTEPH according to international guidelines
* Patients treated for acute PE with anticoagulants for more than 8 months
* Active cancer or in remission for less than two years
* Dyspnea post - COVID due to parenchymal injuries
* Post-COVID hyperventilation syndrome without pulmonary vascular perfusion sequelae.
* Physical or psychological inability to undertake PR
* Isolated or more distal segmental PE
* Neuro-muscular disease with PR contraindication.
* Cardiac insufficiency (unstable coronary artery disease)
* Severe respiratory failure (long-term oxygen therapy, pulmonary hypertension)
* Chronic dyspnea MMRC ≥ 2 before PE
* Cardiac or respiratory rehabilitation in the previous year
* Indication to urgent PR within 6 months at the time of inclusion
* Life expectancy of less than 12 months
* Inability to give consent
* Patient under guardianship or curatorship
* Patient deprived of liberty by an administrative or judicial decision
* Patient has not social security affiliation or who don't beneficiary of such social security

Where it's running

• CHU Brest
  Brest, France, France Recruiting
• CHU Angers
  Angers, France Recruiting
• CHU de Grenoble
  Grenoble, France Recruiting
• CHBS Lorient
  Lorient, France Recruiting
• Hegp (Ap-Hp)
  Paris, France Recruiting
• CHU Saint-Etienne
  Saint-Etienne, France Recruiting

Study contacts

• Study coordinator: Cécile TROMEUR, PH
• Email: cecile.tromeur@chu-brest.fr
• Phone: +33230337602

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.