Reperfusion options for acute pulmonary embolism
Reperfusion Treatment in Acute Pulmonary Embolism: A Multicenter Observational Study in the Nordic Countries
This project will try catheter-directed interventions or systemic thrombolysis in adults with acute pulmonary embolism to see which approach leads to better outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 220 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 13 sites (Aarhus and 12 other locations) |
| Trial ID | NCT07003646 on ClinicalTrials.gov |
What this trial studies
PE-NORDIC is a multicenter observational effort comparing outcomes for adults with acute pulmonary embolism who receive catheter-directed interventions (including mechanical thrombectomy devices such as FlowTriever® and catheter-directed thrombolysis) versus systemic thrombolysis. The study will collect real-world data from participating Nordic hospitals on survival, hemodynamic response, and bleeding complications. It is non-randomized and enrolls patients who are planned for or have already received these reperfusion methods, with a waiver of consent allowed if patients die before consent can be obtained. The project aims to describe how current reperfusion strategies perform in routine clinical practice across the region.
Who should consider this trial
Good fit: Adults (≥18 years) with confirmed acute pulmonary embolism who are planned for or have received catheter-directed intervention or systemic thrombolysis, including pregnant women, are eligible.
Not a fit: Patients undergoing surgical embolectomy as the primary reperfusion treatment or those already enrolled in an interventional catheter-directed trial are not expected to benefit from this observational comparison.
Why it matters
Potential benefit: If successful, it could help identify which reperfusion approach provides better survival and fewer serious bleeding complications for patients with high-risk or deteriorating pulmonary embolism.
How similar studies have performed: Industry-sponsored and single-arm trials have shown promising hemodynamic improvements with devices like FlowTriever, but randomized comparisons between catheter-directed interventions and standard care are still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients (≥18 years), including pregnant women, with verified (CTPA, angiography or scintigraphy) acute pulmonary embolism who are planned for, or have received, treatment with catheter directed intervention or systemic thrombolysis * Informed consent (for patients who do not survive before informed consent can be obtained, a waiver of consent applies) Exclusion Criteria: * Ongoing enrolment in interventional catheter directed intervention trial * Surgical embolectomy as primary reperfusion treatment
Where this trial is running
Aarhus and 12 other locations
- Aarhus University Hospital — Aarhus, Denmark (Recruiting)
- Rigshospitalet — Copenhagen, Denmark (Recruiting)
- Odense University Hospital — Odense, Denmark (Recruiting)
- Sahlgrenska University Hospital — Gothenburg, Sweden (Recruiting)
- Linköping University Hospital — Linköping, Sweden (Recruiting)
- Sunderby Hospital — Luleå, Sweden (Recruiting)
- Skåne University Hospital — Lund, Sweden (Recruiting)
- Örebro University Hospital — Örebro, Sweden (Recruiting)
- Danderyd Hospital — Stockholm, Sweden (Recruiting)
- Karolinska University Hospital Huddinge — Stockholm, Sweden (Recruiting)
- Karolinska University Hospital Solna — Stockholm, Sweden (Recruiting)
- Södersjukhuset — Stockholm, Sweden (Recruiting)
- Uppsala University Hospital — Uppsala, Sweden (Not_yet_recruiting)
Study contacts
- Principal investigator: Kristina Svennerholm, Assoc Prof — Sahlgrenska University Hospital
- Study coordinator: Freyr Einarsson, MD
- Email: freyr.einarsson@vgregion.se
- Phone: +46500 43 10 36
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.