Safer outpatient care options for low-risk pulmonary embolism after an ER visit

Michigan Emergency Department Improvement Collaborative AltERnaTives to admission for Pulmonary Embolism (MEDIC ALERT PE) Study

NIH-funded research University of Michigan at Ann Arbor · NIH-11257997

A program that helps emergency doctors safely treat people with low-risk pulmonary embolism at home with anticoagulant medicines and arranged follow-up.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-11257997 on NIH RePORTER

What this research studies

You would be part of a program rolled out across many emergency departments in Michigan that aims to make it easier for doctors to send low-risk pulmonary embolism patients home instead of admitting them. The team will tailor a multi-part package of supports — such as decision tools for clinicians, reliable access to anticoagulant medicines, and scheduled outpatient follow-up — using input from local hospitals. They will implement this package through the Michigan Emergency Department Improvement Collaborative and track how often patients are treated as outpatients and how they do afterward. The project focuses on real-world emergency care and on making the approach work for diverse hospitals and patients across the state.

Who could benefit from this research

Good fit: People who come to a participating emergency department with an acute pulmonary embolism that clinicians judge to be low risk and who can take anticoagulant medicines and attend outpatient follow-up are the ideal candidates.

Not a fit: Patients who are clinically unstable, judged high-risk for complications, or who cannot reliably access anticoagulant medication or follow-up care are unlikely to benefit from outpatient management.

Why it matters

Potential benefit: If successful, this could reduce unnecessary hospital stays, get patients home sooner with safe treatment, and improve access to timely follow-up care.

How similar studies have performed: Previous single-center and smaller studies have shown that outpatient treatment for selected low-risk PE patients can be safe, but broad multi-site implementation has not been widely tested.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.