Personalized blood thinner treatment for hip and knee replacement patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of individualized thrombosis prophylaxis compared to standard treatment in patients undergoing total hip or knee replacement. It aims to determine if shorter or intensified anticoagulation strategies can reduce the risk of venous thromboembolism (VTE) and bleeding complications based on a patient's specific risk profile. By tailoring the duration and intensity of blood thinner treatment, the study seeks to optimize patient outcomes and minimize unnecessary risks. The research involves comparing different prophylaxis approaches in a diverse patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Scheduled to undergo an elective total hip arthroplasty or total knee arthroplasty
* Aged 18 years or older

Exclusion Criteria:

* Primary arthroplasty for fractures
* Revision surgery
* Hemiarthroplasty
* Pregnancy
* Current use of therapeutic anticoagulant therapy of any type (e.g., LMWH, DOAC, vitamin K antagonist)
* A contraindication for either study drug
* Insufficient knowledge of the Dutch language
* Insufficient mental or physical ability to fulfil trial requirements
* Active malignancy (i.e. cancer diagnosis within six months before surgery (excluding basal-cell or squamous-cell carcinoma of the skin), recently recurrent or progressive cancer or any cancer that required anti-cancer treatment within six months before surgery)
* Patients using thrombocyte aggregation inhibitors that cannot be temporarily discontinued at the discretion of their treating physician

Where it's running

• Gelre Ziekenhuizen
  Apeldoorn, Gelderland, Netherlands Recruiting
• Zuyderland
  Geleen, Limburg, Netherlands Recruiting
• Anna Ziekenhuis
  Geldrop, North Brabant, Netherlands Recruiting
• Elisabeth-TweeSteden Ziekenhuis
  Tilburg, North Brabant, Netherlands Recruiting
• Olvg
  Amsterdam, North Holland, Netherlands Recruiting
• Bergman Clinics
  Naarden, North Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Banne Nemeth, dr — Leiden University Medical Center
• Study coordinator: Banne Nemeth, dr
• Email: B.Nemeth@lumc.nl
• Phone: +31715264037

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.