Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Pharmacy-led intervention to improve medication adherence after hospital discharge

Official title: Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations

Run by University of Tennessee · NCT06374277 · Data updated 2026-11-12

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment388 (estimated)
SponsorUniversity of Tennessee
Academic / other
Locations2 sites (Knoxville, Tennessee and 1 other locations)
StatusRecruiting
StartedApril 6, 2024
Main results expectedDecember 31, 2027
Study endsJanuary 31, 2028
Registry record updatedJanuary 29, 2026
Trial IDNCT06374277 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are Medicaid or uninsured inpatients aged 21 and older with multiple chronic conditions and who are prescribed chronic disease medications.

Probably not a fit

Patients who may not benefit from this study include those who are Medicare and Medicaid dual eligible, have active psychosis or substance abuse issues, or whose primary admission reason is related to cancer or acute surgical procedures.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention aims to address medication nonadherence among socioeconomically disadvantaged patients with multiple chronic conditions after they are discharged from the hospital. The Med AAAction intervention will focus on overcoming barriers related to financial constraints, transportation issues, and system-level challenges that hinder access to essential medications. By implementing a pharmacy-led approach, the study seeks to enhance medication management and adherence during the critical transition from hospital to home. The effectiveness of this intervention will be evaluated in terms of its impact on medication adherence and subsequent health outcomes.

Why it matters

Potential benefit: If successful, this intervention could significantly improve medication adherence and health outcomes for patients with chronic conditions, reducing readmissions and healthcare costs.

How similar studies have gone: Other studies have shown mixed results with similar approaches, indicating a need for innovative interventions like this one to effectively improve medication adherence.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Medicaid or uninsured inpatients
* 21 years or older
* ≥2 of the complex chronic conditions during index admission or prescribed/using ≥2 chronic medications for these conditions
* Patients receiving chronic disease medications from the hospital pharmacy.
* Patients will be eligible if they have multiple complex chronic conditions including diabetes, hypertension, high cholesterol, coronary artery disease, congestive heart failure, chronic lung disease, chronic kidney disease, arrhythmia, stroke, psychiatric disorders including depression and anxiety, or who are prescribed or using anticoagulants.

Exclusion Criteria:

* Medicare and Medicaid dual eligible patients.
* If the primary reason for the index admission is related to cancer, pregnancy, or a surgical procedure for an acute problem
* If patients have diagnoses of active psychosis, substance abuse, or suicidal ideation during the index admission.
* If the planned discharge location is not home.
* If patients are part of an existing pharmacy discharge program.

Where it's running

  • University of Tennessee Health Science Center/Regional One Health
    Memphis, Tennessee, United States
    Recruiting
  • University of Tennessee Medical Center
    Knoxville, Tennessee, United States
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.