Using breath analysis to identify multiple lung diseases
Official title: Exploration and Study on the Identification of Various Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath
Run by ChromX Health · NCT06528418 · Data updated 2026-11-12
This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | ChromX Health Industry-sponsored |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | June 30, 2024 |
| Main results expected | December 30, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | March 26, 2025 |
| Trial ID | NCT06528418 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with a clear clinical diagnosis of various pulmonary diseases and the ability to provide CT imaging data.
✕Probably not a fit
Patients who are pregnant, have a history of cancers other than lung disease, or have severe organic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to develop an advanced algorithm that utilizes volatile organic compounds (VOCs) found in exhaled breath to diagnose various pulmonary diseases. It will recruit 10,000 participants with conditions such as lung cancer, COPD, and bronchitis, collecting breath samples for analysis using gas chromatography techniques. The study will evaluate the diagnostic accuracy of an AI model based on these breath samples, comparing results with clinical diagnostic data and imaging results.
Why it matters
Potential benefit: If successful, this approach could lead to earlier and more accurate diagnoses of multiple pulmonary diseases, improving patient outcomes.
How similar studies have gone: While the use of breath analysis for disease diagnosis is an emerging field, similar studies have shown promise in identifying specific conditions, making this approach both innovative and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males or females, age must be 18 years old or above. * Patients must meet the CT imaging diagnostic criteria for different lung diseases, and patients must be able to provide electronic versions of CT image data. * Patients must have a clear clinical diagnosis. * All participants must sign a written informed consent form. Exclusion Criteria: * Pregnant women. * Individuals with a history of cancer other than lung disease. * Individuals who have undergone organ transplants or non-autologous (allogeneic) bone marrow or stem cell transplants. * Individuals with other severe organic diseases or mental illnesses. * Individuals with metabolic diseases such as diabetes, hyperlipidemia, etc. * Any other condition that researchers deem unsuitable for participation in this clinical trial.
Where it's running
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The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Hengrui Liang, MD
- Email: hengrui_liang@163.com
- Phone: +86 15625064712
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.