Pulmonary embolism: catheter-directed clot removal for better outcomes

Who could benefit from this research

What this research studies

If you have submassive PE with right heart strain but stable blood pressure, this study looks at catheter-directed therapy as an alternative to standard care. Participants are randomly assigned to receive CDT or not, and the study includes careful monitoring of heart and lung function over time. The trial is designed to adapt as results come in, with measurements focused on short-term fitness and long-term daily function. It’s conducted at New York University School of Medicine and aims to enroll up to 500 patients. The researchers will compare outcomes such as peak oxygen use at 3 months and NYHA class at 12 months to determine if CDT offers meaningful benefits with acceptable safety.

Why it matters

Where this research is happening

• New York University School of Medicine
  New York, United States Active

Researchers

• Principal investigator: Troxel, Andrea B — New York University School of Medicine
• Study coordinator: Troxel, Andrea B

Related research

Other NIH-funded projects on the same topics.

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• Supplemental Oxygen for Pulmonary Embolism: A Mechanistic Look at How Oxygen Helps the Heart and Lungs

  This NIH grant tests how giving extra oxygen affects lung pressure and heart strain in people with acute pulmonary embolism, with supportive animal studies to understand the biology.

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• Pulmonary embolism treatment with catheter-directed thrombus removal versus no catheter therapy

  This study tests whether removing clot with a targeted catheter approach helps people with submassive pulmonary embolism feel better and move more easily, compared with not using catheter therapy.

  NIH research New York University School of Medicine · New York, United States · NIH-11381072

• Molecular and imaging study of blood clots and inflammation in pulmonary embolism

  A research project uses a mouse model to understand how blood clots and inflammatory cells affect pulmonary embolism and its outcomes, with the goal of better diagnosis and treatment for people with PE.

  NIH research Masonic Medical Research Laboratory, INC · Utica, United States · NIH-11333828

• Helping ER doctors use a pulmonary embolism risk tool

  This project adds simple behavioral "nudges" to an electronic pulmonary embolism risk tool to help ER doctors pick the right patients for CT scans, aiming to cut down on unnecessary scans for people with suspected PE.

  NIH research New York University School of Medicine · New York, United States · NIH-11333795

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.