Early detection of deep vein thrombosis in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates whether regular ultrasound screenings can help detect deep vein thrombosis (DVT) in critically ill patients, potentially reducing the risk of pulmonary embolism (PE) and lowering overall mortality rates within 90 days. Patients admitted to the ICU will be screened for eligibility and randomized to receive either twice-weekly ultrasounds of their lower limbs or standard care. The study aims to determine if proactive monitoring can improve patient outcomes in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion criteria

1. Medical, surgical or trauma ICU patients ≥18 years old.
2. Patients who are expected to stay in the ICU more than 2 calendar days (unlikely to be discharged out of ICU on the day of admission or on the next day).

Exclusion Criteria

1. Patients with DVT or PE diagnosed within the last year.
2. Patients receiving chronic systemic anticoagulation.
3. Patients who have received up to the time of ICU admission or are receiving therapeutic doses of anticoagulation with UFH, LMWH, or other anticoagulants.
4. Inability or contraindication to obtain adequate ultrasound on the lower extremities (Burns in the lower extremities, lacerations, active skin infection, \& ischemic limb in the legs, large dressings in the thighs that prevent adequate ultrasounds OR amputated foot or leg on one or two sides)
5. Patients with Inferior Vena Cava (IVC) Filter.
6. Known or suspected pregnancy.
7. Limitation of life support, life expectancy \<7 days or palliative care.
8. Previously enrolled in DETECT trial within the last 180 days.
9. Enrolled in another trial for which co-enrolment is not approved.

Where it's running

• King Abdulaziz Medical City
  Riyadh, Riyadh Region, Saudi Arabia Recruiting

Study contacts

• Principal investigator: Yaseen M Arabi — King Saud bin Abdulaziz University of Health Sciences
• Study coordinator: Yaseen M Arabi
• Email: yaseenarabi@yahoo.com
• Phone: +966118011111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.