Removing blood clots in patients with pulmonary embolism using catheter therapy
Official title: 2/2 Pulmonary Embolism: Thrombus Removal with Catheter-Directed Therapy (PE-TRACT Trial) –DCC
Funded at New York University School of Medicine · NIH-10928723 · Data updated 2026-11-12
This study is looking at how well a special treatment called catheter-directed therapy (CDT) works for people with submassive pulmonary embolism (PE), which is when blood clots block blood flow to the lungs, and it will compare the results of those who get this treatment to those who don’t, all while aiming to help improve heart and lung health with less risk of bleeding.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $540,232 |
| NIH project number | 5U24HL155811-03 |
| Project ID | NIH-10928723 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with submassive pulmonary embolism who exhibit right heart dysfunction but maintain normal blood pressure.
✕Less likely to help
Patients with severe pulmonary embolism or those who do not have right heart dysfunction may not benefit from this research.
What this research studies
This research investigates the effectiveness of catheter-directed therapy (CDT) for patients suffering from submassive pulmonary embolism (PE), a condition where blood clots block blood flow to the lungs. The study aims to compare the outcomes of patients receiving CDT against those who do not receive this treatment. By using a lower dose of thrombolytic drugs, CDT may reduce the risk of severe bleeding while still improving heart and lung function. The trial will involve up to 500 patients and will assess both short-term and long-term health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment options for patients with pulmonary embolism, improving their quality of life and functional capacity.
How similar studies have gone: Previous research has shown promising results with catheter-directed therapy in similar patient populations, indicating potential for success in this trial.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Troxel, Andrea B — New York University School of Medicine
- Study coordinator: Troxel, Andrea B
Related research
Other NIH-funded projects on the same topics.
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AI-powered tool to better predict and manage acute pulmonary embolism
A new AI system uses imaging and patient data to improve how doctors predict short-term risk and tailor treatment for people with acute pulmonary embolism.
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Endovascular vortex ultrasound to treat blood clots in the lungs
A new therapy uses a tiny ultrasound device inside the blood vessels to rapidly dissolve clots in the lungs of people with pulmonary embolism, aiming to reduce the need for high doses of clot-busting drugs.
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Supplemental Oxygen for Pulmonary Embolism: A Mechanistic Look at How Oxygen Helps the Heart and Lungs
This NIH grant tests how giving extra oxygen affects lung pressure and heart strain in people with acute pulmonary embolism, with supportive animal studies to understand the biology.
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Pulmonary embolism: catheter-directed clot removal for better outcomes
This trial tests whether delivering clot-dissolving medication directly to the lungs via a catheter helps people with submassive pulmonary embolism feel better and function better, with fewer bleeding risks.
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Pulmonary embolism treatment with catheter-directed thrombus removal versus no catheter therapy
This study tests whether removing clot with a targeted catheter approach helps people with submassive pulmonary embolism feel better and move more easily, compared with not using catheter therapy.
-
Molecular and imaging study of blood clots and inflammation in pulmonary embolism
A research project uses a mouse model to understand how blood clots and inflammatory cells affect pulmonary embolism and its outcomes, with the goal of better diagnosis and treatment for people with PE.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.