Pulmonary embolism treatment with catheter-directed thrombus removal versus no catheter therapy

Who could benefit from this research

What this research studies

If you have submassive pulmonary embolism with right heart strain, this trial will compare catheter-directed therapy to not using catheter therapy. It uses adaptive enrollment and blinded assessment to measure short-term fitness (peak oxygen use at 3 months) and long-term heart–lung function (NYHA class at 12 months). The study aims to see if a targeted, lower-dose clot-busting treatment can provide similar benefits to systemic therapy but with less bleeding, potentially improving quality of life over time. Participants will be randomly assigned to CDT or no-CDT and will be monitored for safety and outcomes through follow-ups coordinated by NYU School of Medicine. An interim analysis could stop the trial early if results are clearly superior or futile.

Why it matters

Where this research is happening

• New York University School of Medicine
  New York, United States Active

Researchers

• Principal investigator: Rao, Sunil V — New York University School of Medicine
• Study coordinator: Rao, Sunil V

Related research

Other NIH-funded projects on the same topics.

• AI-powered tool to better predict and manage acute pulmonary embolism

  A new AI system uses imaging and patient data to improve how doctors predict short-term risk and tailor treatment for people with acute pulmonary embolism.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11452851

• Endovascular vortex ultrasound to treat blood clots in the lungs

  A new therapy uses a tiny ultrasound device inside the blood vessels to rapidly dissolve clots in the lungs of people with pulmonary embolism, aiming to reduce the need for high doses of clot-busting drugs.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11448155

• Supplemental Oxygen for Pulmonary Embolism: A Mechanistic Look at How Oxygen Helps the Heart and Lungs

  This NIH grant tests how giving extra oxygen affects lung pressure and heart strain in people with acute pulmonary embolism, with supportive animal studies to understand the biology.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11401200

• Pulmonary embolism: catheter-directed clot removal for better outcomes

  This trial tests whether delivering clot-dissolving medication directly to the lungs via a catheter helps people with submassive pulmonary embolism feel better and function better, with fewer bleeding risks.

  NIH research New York University School of Medicine · New York, United States · NIH-11384861

• Molecular and imaging study of blood clots and inflammation in pulmonary embolism

  A research project uses a mouse model to understand how blood clots and inflammatory cells affect pulmonary embolism and its outcomes, with the goal of better diagnosis and treatment for people with PE.

  NIH research Masonic Medical Research Laboratory, INC · Utica, United States · NIH-11333828

• Helping ER doctors use a pulmonary embolism risk tool

  This project adds simple behavioral "nudges" to an electronic pulmonary embolism risk tool to help ER doctors pick the right patients for CT scans, aiming to cut down on unnecessary scans for people with suspected PE.

  NIH research New York University School of Medicine · New York, United States · NIH-11333795

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.