Investigating the link between clonal hematopoiesis and unprovoked pulmonary embolism
Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
This study is trying to see if a blood condition called clonal hematopoiesis is common in people who have had a sudden pulmonary embolism without any clear cause.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 544 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Trial ID | NCT04711746 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the association between clonal hematopoiesis of indeterminate potential (CHIP) and unprovoked pulmonary embolism. It will involve analyzing blood samples from patients who have experienced unprovoked pulmonary embolism and comparing them to those with provoked pulmonary embolism. The research seeks to determine if CHIP is a frequent occurrence in these patients and whether it plays a role in the underlying mechanisms of the condition.
Who should consider this trial
Good fit: Ideal candidates include individuals who have had a previous proximal unprovoked pulmonary embolism with negative thrombophilia screening.
Not a fit: Patients over 65 years old or those with active cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the risk factors for unprovoked pulmonary embolism and lead to improved prevention strategies.
How similar studies have performed: While the investigation of CHIP in relation to pulmonary embolism is a novel approach, previous studies have linked CHIP to other vascular conditions, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening. * For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening. Exclusion Criteria: * Age superior to 65 years old, * Active cancer
Where this trial is running
Amiens
- CHU Amiens — Amiens, France (Recruiting)
Study contacts
- Study coordinator: Simon SOUDET, MD
- Email: soudet.simon@chu-amiens.fr
- Phone: 03 22 88 72 89
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.