Investigating the link between clonal hematopoiesis and unprovoked pulmonary embolism
Official title: Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
Run by Centre Hospitalier Universitaire, Amiens · NCT04711746 · Data updated 2026-11-12
This study is trying to see if a blood condition called clonal hematopoiesis is common in people who have had a sudden pulmonary embolism without any clear cause.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 544 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | February 1, 2021 |
| Main results expected | January 2026 |
| Study ends | January 2026 |
| Registry record updated | May 29, 2025 |
| Trial ID | NCT04711746 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals who have had a previous proximal unprovoked pulmonary embolism with negative thrombophilia screening.
✕Probably not a fit
Patients over 65 years old or those with active cancer may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the association between clonal hematopoiesis of indeterminate potential (CHIP) and unprovoked pulmonary embolism. It will involve analyzing blood samples from patients who have experienced unprovoked pulmonary embolism and comparing them to those with provoked pulmonary embolism. The research seeks to determine if CHIP is a frequent occurrence in these patients and whether it plays a role in the underlying mechanisms of the condition.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the risk factors for unprovoked pulmonary embolism and lead to improved prevention strategies.
How similar studies have gone: While the investigation of CHIP in relation to pulmonary embolism is a novel approach, previous studies have linked CHIP to other vascular conditions, suggesting potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening. * For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening. Exclusion Criteria: * Age superior to 65 years old, * Active cancer
Where it's running
-
CHU Amiens
Amiens, France Recruiting
Study contacts
- Study coordinator: Simon SOUDET, MD
- Email: soudet.simon@chu-amiens.fr
- Phone: 03 22 88 72 89
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.