Using supplemental oxygen to treat pulmonary embolism
Supplemental Oxygen for Pulmonary Embolism (SO-PE) - A Mechanistic Clinical Trial
This study is looking at how extra oxygen might help people with acute pulmonary embolism by easing pressure in the lungs and helping the heart work better, and it will involve patients in the emergency department at Massachusetts General Hospital as well as some research with pigs to see if the same benefits can apply to humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10918051 on NIH RePORTER |
What this research studies
This research investigates how supplemental oxygen can help patients suffering from acute pulmonary embolism (PE) by reducing pressure in the pulmonary artery and improving heart function. The study will involve patients in the emergency department at Massachusetts General Hospital, where experienced researchers will monitor the effects of oxygen therapy. Additionally, a porcine model will be used to understand the underlying mechanisms of how oxygen alleviates symptoms of PE. The goal is to determine if the benefits observed in pigs can also be applied to human patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute pulmonary embolism who are receiving treatment in the emergency department.
Not a fit: Patients with chronic pulmonary conditions or those who do not have acute pulmonary embolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for patients with acute pulmonary embolism, potentially saving lives and enhancing recovery.
How similar studies have performed: Previous studies have shown that supplemental oxygen can have beneficial effects in similar acute conditions, suggesting a promising avenue for this research.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kabrhel, Christopher — Massachusetts General Hospital
- Study coordinator: Kabrhel, Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.