Investigating blood clot formation and inflammation in pulmonary embolism
Molecular and morphometric imaging of coagulation and inflammation in pulmonary embolism pathogenesis
['FUNDING_R01'] · MASONIC MEDICAL RESEARCH LABORATORY, INC · NIH-10980911
This study is looking at how blood clots form and cause lung inflammation in people with pulmonary embolism, using a special mouse model to help find better ways to diagnose and treat patients who might be at risk for complications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASONIC MEDICAL RESEARCH LABORATORY, INC (nih funded) |
| Locations | 1 site (UTICA, UNITED STATES) |
| Trial ID | NIH-10980911 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how blood clots form and cause inflammation in the lungs during pulmonary embolism (PE). Using a unique mouse model, researchers will create blood clots in the veins and then observe their effects when these clots travel to the lungs. This approach allows for detailed analysis of the clots' composition and the body's inflammatory response over time, which could lead to better diagnostic and treatment strategies for patients with PE. The study aims to improve patient outcomes by identifying which patients are at higher risk for complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for pulmonary embolism, particularly those with intermediate or low-risk profiles.
Not a fit: Patients who have already experienced severe complications from pulmonary embolism or those with contraindications to participation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients suffering from pulmonary embolism.
How similar studies have performed: Previous research has shown promise in using animal models to study pulmonary embolism, but this specific approach is relatively novel.
Where this research is happening
UTICA, UNITED STATES
- MASONIC MEDICAL RESEARCH LABORATORY, INC — UTICA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KESSINGER, CHASE WILLIAM — MASONIC MEDICAL RESEARCH LABORATORY, INC
- Study coordinator: KESSINGER, CHASE WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.