Investigating blood clot formation and inflammation in pulmonary embolism
Official title: Molecular and morphometric imaging of coagulation and inflammation in pulmonary embolism pathogenesis
Funded at Masonic Medical Research Laboratory, INC · NIH-10980911 · Data updated 2026-11-12
This study is looking at how blood clots form and cause lung inflammation in people with pulmonary embolism, using a special mouse model to help find better ways to diagnose and treat patients who might be at risk for complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Masonic Medical Research Laboratory, INC NIH-funded |
| Lab location | 1 site (Utica, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $728,651 |
| NIH project number | 1R01HL158816-01A1 |
| Project ID | NIH-10980911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for pulmonary embolism, particularly those with intermediate or low-risk profiles.
✕Less likely to help
Patients who have already experienced severe complications from pulmonary embolism or those with contraindications to participation may not benefit from this research.
What this research studies
This research focuses on understanding how blood clots form and cause inflammation in the lungs during pulmonary embolism (PE). Using a unique mouse model, researchers will create blood clots in the veins and then observe their effects when these clots travel to the lungs. This approach allows for detailed analysis of the clots' composition and the body's inflammatory response over time, which could lead to better diagnostic and treatment strategies for patients with PE. The study aims to improve patient outcomes by identifying which patients are at higher risk for complications.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients suffering from pulmonary embolism.
How similar studies have gone: Previous research has shown promise in using animal models to study pulmonary embolism, but this specific approach is relatively novel.
Where this research is happening
-
Masonic Medical Research Laboratory, INC
Utica, United States Active
Researchers
- Principal investigator: Kessinger, Chase William — Masonic Medical Research Laboratory, INC
- Study coordinator: Kessinger, Chase William
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-
Molecular and imaging study of blood clots and inflammation in pulmonary embolism
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.