Chair lift test to predict outcomes after non-severe pulmonary embolism
Official title: Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study
Run by University Hospital, Rouen · NCT06166329 · Data updated 2026-11-12
We will test whether a chair lift test can help predict short-term outcomes for hospitalized adults with non-severe pulmonary embolism.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | University Hospital, Rouen Academic / other |
| Locations | 1 site (Rouen) |
| Status | Recruiting |
| Started | February 9, 2024 |
| Main results expected | February 2027 |
| Study ends | February 2027 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT06166329 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults hospitalized with confirmed non-severe pulmonary embolism who are anticoagulated, not on supplemental oxygen, and meet sPESI-based inclusion criteria (sPESI ≥1 or sPESI = 0 with elevated troponin or RV dysfunction or with hospitalization needs unrelated to PE).
✕Probably not a fit
Patients with high-risk pulmonary embolism requiring ICU-level interventions, those on oxygen, or those whose diagnosis was confirmed more than 24 hours after suspicion are unlikely to benefit from this test.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, open prospective study that uses a simple chair lift test performed early during hospitalization after diagnosis of non-severe pulmonary embolism. Investigators will compare the prognostic performance of the chair lift test against current risk stratification using the sPESI score refined by cardiac biomarkers and evidence of right ventricular dysfunction. Eligible patients are those confirmed by thoracic CT angiography or ventilation-perfusion scan, anticoagulated, and without need for intensive therapies or supplemental oxygen at the time of testing. The main goal is to determine whether the chair lift test can identify patients at higher risk of short-term complications or need for escalated care.
Why it matters
Potential benefit: If successful, the chair lift test could provide a quick, bedside way to identify patients who may need closer monitoring or treatment changes.
How similar studies have gone: Functional exertion tests have been used in other cardiopulmonary contexts, but using a chair lift test specifically for PE prognostic stratification is relatively novel with limited prior evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of pulmonary embolism according to clinical algorithm, confirmed by thoracic angioscan or ventilation perfusion (V/P) scan, * Non-serious pulmonary embolism, not requiring intensive care (thrombectomy or fibrinolysis not considered). * sPESI score ≥ 1 \[or = 0 with elevated troponin or presence of markers of VD dysfunction, or = 0 with need for hospitalization due to comorbidities unrelated to PE (social isolation, comprehension disorders, intercurrent infection, chronic renal failure, advanced cancer...) * Patients with no contraindications to chair lift testing (no O2 at the time of testing). * Effective anticoagulation for at least 1 hour. Exclusion Criteria: * sPESI score = 0 with outpatient referral. * Diagnostic confirmation of Pulmonia Embolism by thoracic angioscan or scintigraphy more than 24h after suspicion of diagnosis. * Hospitalization \> 24h after introduction of anticoagulation, with subsequent confirmation by scintigraphy. * Any sign of serious Pulmonia Embolism, requiring hospitalization in an intensive care unit. * Asymptomatic Pulmonia Embolism discovered by chance
Where it's running
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Chu Rouen
Rouen, France Recruiting
Study contacts
- Principal investigator: Delphine SIMON, MD — University Hospital, Rouen
- Study coordinator: Delphine SIMON, MD
- Email: delphine.simon@chu-rouen.fr
- Phone: 2 32 88 73 97
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.