Chair lift test to predict outcomes after non-severe pulmonary embolism

Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study

We will test whether a chair lift test can help predict short-term outcomes for hospitalized adults with non-severe pulmonary embolism.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 180 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University Hospital, Rouen (other)
• Locations: 1 site (Rouen)
• Trial ID: NCT06166329 on ClinicalTrials.gov

What this trial studies

This is a single-center, open prospective study that uses a simple chair lift test performed early during hospitalization after diagnosis of non-severe pulmonary embolism. Investigators will compare the prognostic performance of the chair lift test against current risk stratification using the sPESI score refined by cardiac biomarkers and evidence of right ventricular dysfunction. Eligible patients are those confirmed by thoracic CT angiography or ventilation-perfusion scan, anticoagulated, and without need for intensive therapies or supplemental oxygen at the time of testing. The main goal is to determine whether the chair lift test can identify patients at higher risk of short-term complications or need for escalated care.

Who should consider this trial

Good fit: Adults hospitalized with confirmed non-severe pulmonary embolism who are anticoagulated, not on supplemental oxygen, and meet sPESI-based inclusion criteria (sPESI ≥1 or sPESI = 0 with elevated troponin or RV dysfunction or with hospitalization needs unrelated to PE).

Not a fit: Patients with high-risk pulmonary embolism requiring ICU-level interventions, those on oxygen, or those whose diagnosis was confirmed more than 24 hours after suspicion are unlikely to benefit from this test.

Why it matters

Potential benefit: If successful, the chair lift test could provide a quick, bedside way to identify patients who may need closer monitoring or treatment changes.

How similar studies have performed: Functional exertion tests have been used in other cardiopulmonary contexts, but using a chair lift test specifically for PE prognostic stratification is relatively novel with limited prior evidence.

Eligibility criteria

Inclusion Criteria:

* Diagnosis of pulmonary embolism according to clinical algorithm, confirmed by thoracic angioscan or ventilation perfusion (V/P) scan,
* Non-serious pulmonary embolism, not requiring intensive care (thrombectomy or fibrinolysis not considered).
* sPESI score ≥ 1 \[or = 0 with elevated troponin or presence of markers of VD dysfunction, or = 0 with need for hospitalization due to comorbidities unrelated to PE (social isolation, comprehension disorders, intercurrent infection, chronic renal failure, advanced cancer...)
* Patients with no contraindications to chair lift testing (no O2 at the time of testing).
* Effective anticoagulation for at least 1 hour.

Exclusion Criteria:

* sPESI score = 0 with outpatient referral.
* Diagnostic confirmation of Pulmonia Embolism by thoracic angioscan or scintigraphy more than 24h after suspicion of diagnosis.
* Hospitalization \> 24h after introduction of anticoagulation, with subsequent confirmation by scintigraphy.
* Any sign of serious Pulmonia Embolism, requiring hospitalization in an intensive care unit.
* Asymptomatic Pulmonia Embolism discovered by chance

Where this trial is running

Rouen

• Chu Rouen — Rouen, France (RECRUITING)

Study contacts

• Principal investigator: Delphine SIMON, MD — University Hospital, Rouen
• Study coordinator: Delphine SIMON, MD

Conditions: Non-severe Pulmonary Embolism, Pulmonary Embolism, Non-high-risk Pulmonary Embolism, Pulmonary Embolism Acute, Prognostic Stratification, Risk Assessment in Pulmonary Embolism, Functional Exercise Testing, Early Prognostic Evaluation