Post‑operative pain after root canal using resin versus bioceramic sealers
Comparison of Post Operative Pain in Resin-Based and Bio Ceramic Based Root Canal Sealer in Patient Presenting at Peshawar Dental College
NA · Prime Foundation · NCT07253025
This study will test whether adults who receive a resin-based sealer or a bioceramic sealer during root canal treatment have different amounts of pain in the first 48 hours.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 17 Years to 70 Years |
| Sex | All |
| Sponsor | Prime Foundation (other) |
| Locations | 1 site (Peshawar, Khyber Pakhtoon Khawa(KPK)a) |
| Trial ID | NCT07253025 on ClinicalTrials.gov |
What this trial studies
Adults with symptomatic irreversible pulpitis in single-rooted maxillary or mandibular teeth presenting to Peshawar Dental College will be enrolled and allocated to receive either a resin-based or a bioceramic root canal sealer during endodontic treatment. Post-operative pain will be recorded using a 0–10 Visual Analog Scale at 24 and 48 hours, with pain considered present if VAS > 3. The planned sample size is 180 participants, with 90 in each sealer group. Key exclusions include immature apices, root resorption, current analgesic/anti-inflammatory use, pregnancy or lactation, medical compromise, and acute flare-ups.
Who should consider this trial
Good fit: Adults aged 18–70 with symptomatic irreversible pulpitis in a single-rooted maxillary or mandibular tooth who are not pregnant, not on analgesic or anti-inflammatory medications, and medically fit are the ideal candidates.
Not a fit: Patients with multi-rooted teeth, immature apices, root resorption, current analgesic/anti-inflammatory use, medical compromise, pregnancy/lactation, or those presenting with a flare-up are unlikely to benefit from this comparison.
Why it matters
Potential benefit: If successful, the results could help dentists choose a sealer that reduces short-term pain after root canal treatment.
How similar studies have performed: Previous small clinical studies have compared resin and bioceramic sealers with mixed results, so evidence on which sealer produces less post-operative pain remains inconclusive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Gender Both males and females * Age Group (18-70) Years * Patients with Mandibular or Maxillary single-rooted teeth identified with symptomatic irreversible pulpitis either with symptomatic apical periodontitis or normal apical tissues Exclusion Criteria: * Patients with immature apices * Patients with root resorption * Patients medically compromised, Patients on medications i.e analgesic or anti-inflammatory drugs, * pregnant/lactating females * Patient came with flare up pain * Patients who refused to participate in this study.
Where this trial is running
Peshawar, Khyber Pakhtoon Khawa(KPK)a
- Peshawar Dental Collge — Peshawar, Khyber Pakhtoon Khawa(KPK)a, Pakistan (RECRUITING)
Study contacts
- Principal investigator: Dr. Shah Zaman, BDS
- Study coordinator: Dr. Shah Zaman, BDS
- Email: zshah5778@gmail.com
- Phone: 0092 3159393980
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Post Operative Pain