Clinical trial Recruiting at 1 site Interventional Ages 17 to 70

Post‑operative pain after root canal using resin versus bioceramic sealers

Official title: Comparison of Post Operative Pain in Resin-Based and Bio Ceramic Based Root Canal Sealer in Patient Presenting at Peshawar Dental College

Run by Prime Foundation · NCT07253025 · Data updated 2026-11-12

This study will test whether adults who receive a resin-based sealer or a bioceramic sealer during root canal treatment have different amounts of pain in the first 48 hours.

Quick facts

Study typeInterventional
Ages17 Years to 70 Years
SexAll
Enrollment180 (estimated)
SponsorPrime Foundation
Academic / other
Locations1 site (Peshawar, Khyber Pakhtoon Khawa(KPK)a)
StatusRecruiting
StartedNovember 30, 2025
Main results expectedApril 2, 2026
Study endsApril 2, 2026
Registry record updatedNovember 28, 2025
Trial IDNCT07253025 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–70 with symptomatic irreversible pulpitis in a single-rooted maxillary or mandibular tooth who are not pregnant, not on analgesic or anti-inflammatory medications, and medically fit are the ideal candidates.

Probably not a fit

Patients with multi-rooted teeth, immature apices, root resorption, current analgesic/anti-inflammatory use, medical compromise, pregnancy/lactation, or those presenting with a flare-up are unlikely to benefit from this comparison.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with symptomatic irreversible pulpitis in single-rooted maxillary or mandibular teeth presenting to Peshawar Dental College will be enrolled and allocated to receive either a resin-based or a bioceramic root canal sealer during endodontic treatment. Post-operative pain will be recorded using a 0–10 Visual Analog Scale at 24 and 48 hours, with pain considered present if VAS > 3. The planned sample size is 180 participants, with 90 in each sealer group. Key exclusions include immature apices, root resorption, current analgesic/anti-inflammatory use, pregnancy or lactation, medical compromise, and acute flare-ups.

Why it matters

Potential benefit: If successful, the results could help dentists choose a sealer that reduces short-term pain after root canal treatment.

How similar studies have gone: Previous small clinical studies have compared resin and bioceramic sealers with mixed results, so evidence on which sealer produces less post-operative pain remains inconclusive.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Gender Both males and females
* Age Group (18-70) Years
* Patients with Mandibular or Maxillary single-rooted teeth identified with symptomatic irreversible pulpitis either with symptomatic apical periodontitis or normal apical tissues

Exclusion Criteria:

* Patients with immature apices
* Patients with root resorption
* Patients medically compromised, Patients on medications i.e analgesic or anti-inflammatory drugs,
* pregnant/lactating females
* Patient came with flare up pain
* Patients who refused to participate in this study.

Where it's running

  • Peshawar Dental Collge
    Peshawar, Khyber Pakhtoon Khawa(KPK)a, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.