Intrathecal versus epidural morphine for pain after cesarean delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This unicentric randomized clinical trial will enroll pregnant women undergoing elective cesarean delivery at Hospital Central do Funchal. Participants will be randomly assigned to receive either 80 mcg intrathecal morphine at the end of surgery or epidural morphine given as a 2.5 mg bolus at the end of surgery with a second 2.5 mg bolus 24 hours later. The primary outcome is pain intensity during the first 24 postoperative hours, and secondary outcomes include pain at 48 hours, need for rescue analgesia, sedation, nausea/vomiting, pruritus, impact on mobilization and maternal satisfaction. Outcomes will be collected during the immediate postoperative period and up to 48 hours to compare analgesic effectiveness and side-effect profiles.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant women scheduled for elective cesarean section;
* Age \> 18 years;
* Willingness to participate in the study, as demonstrated by signed informed consent.

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status classification \> III;
* Chronic kidney disease with a glomerular filtration rate \< 60 mL/min;
* Relevant drug allergies (particularly to protocol medications);
* Opioid tolerance;
* Contraindication to neuraxial anesthetic techniques.

Where it's running

• Hospital Central do Funchal
  Funchal, Madeira, Portugal Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sedation and pain control for adults with fractures and dislocations in the emergency department

  This project will try different sedation and pain-control methods to see which gives adults the best pain relief and satisfaction during emergency-room reductions of fractures or dislocations.

  Recruiting at 3 sites Region Zealand · Holbæk, Region Sjælland and 2 other locations · NCT07314450

• Using a number-based pain score plus a simple activity score to guide rescue pain medicine after surgery

  This project will test whether using a combined numerical pain score and a simple Functional Activity Score to decide when to give rescue pain medicine helps adults recover after surgery.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo · NCT07310953

• Ultrasound-guided auricularis magnus nerve block to reduce pain after middle ear surgery

  This study will test whether an ultrasound-guided auricularis magnus nerve block reduces postoperative pain and bleeding in adults having middle ear surgery.

  Recruiting Kocaeli University · Istanbul · NCT06869967

• Using Vitamin B Complex for Pain Relief After Cesarean Section

  This study is testing if adding vitamin B complex to standard pain relief methods can help women recover better after a cesarean section while reducing the need for opioids.

  Recruiting Ain Shams University · Cairo, Egypt · NCT06446830

• Comparing nerve block and morphine for pain relief after hip surgery

  This study tests whether a nerve block can provide the same pain relief as morphine for people recovering from hip surgery.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT06317870

• Comparing high and low dose pain relief methods after heart valve surgery

  This study is testing whether a high or low dose of a new pain relief method can help patients after heart valve surgery feel less pain and use fewer opioids.

  Recruiting Jessa Hospital · Hasselt, Limburg · NCT06205875

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.