Magnesium given during colorectal cancer surgery to see if it lowers inflammation afterward

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study administers intravenous magnesium sulfate during open colorectal cancer surgery to see if it lowers postoperative inflammatory markers such as CRP, white blood cells, and neutrophil count. Patients are adults (35–75) with ASA I–II undergoing surgery at Ain Shams University, with standard anesthesia and monitoring per hospital protocol. Intraoperative data and postoperative pain via the Visual Analogue Scale will be collected, along with routine labs and complications, to assess the inflammatory response. The study compares magnesium sulfate to normal saline as the control. Recruitment and consent occur preoperatively, and safety monitoring follows institutional guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA I and ASA II.
* Age (35yrs - 75yrs).
* Patients undergoing open colorectal cancer surgery.
* Sex: Both sexes.

Exclusion Criteria:

* Renal impairment (Glomerular Filtration Rate \< 60 ml\\min).
* Severe cardiac dysfunction (Ejection fraction ≤ 30% or clinical signs and symptoms of reduced left ventricular ejection fraction), preoperative bradycardia (HR \< 50 bpm) and atrioventricular block (first, second and third degree).
* Allergy to study drug (MgSO4).
* Patient refusal to precipitate in this study.
* Autoimmune disorders (eg: rheumatoid arthritis, multiple sclerosis and lupus), congenital and acquired immunodeficiency.
* Previous / current immunomodulatory therapy.
* Emergency condition (eg: obstruction or perforation in colorectal cancer).
* Postoperative complications altering inflammatory response (eg: infection, anastomotic leak).
* Duration of operation \> 5 hours.
* Cognitive impairment (eg: Dementia) and other psychiatric disorders by history.
* Body mass index less than 18 or greater than 30 kg/m².

Where it's running

• Ain shams university
  Cairo, Abbassia, Egypt Recruiting

Study contacts

• Study coordinator: Nada sami abdelfattah mohammed, M.Sc.
• Email: NadaSamiAbdelfattah@med.asu.edu.eg
• Phone: +201095640453

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.