Nano-sized intracanal medications to reduce periapical inflammation after root canal retreatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Sixty-three patients with previously treated single-rooted teeth and periapical radiolucency will be randomized into three equal groups to receive either nano-chitosan paste, nano-calcium hydroxide paste, or standard calcium hydroxide as intracanal medicament. Retreatment procedures include gutta-percha removal, standardized rotary instrumentation, irrigation, and microbiologic sampling before medicament placement. Group assignment is concealed using sequentially numbered opaque envelopes and simple randomization. Outcomes focus on periapical inflammation and post-operative pain following the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients have single rooted teeth with root canal form type I. Have previous endodontic therapy with failure. Have periapical radiolucency (PAI score of 3 or 4). Asymptomatic patients who had no pain or swelling, had a negative response to palpation and percussion.

Exclusion Criteria:

Patients who had received antibiotic therapy within the past 3 months. Pregnancy and lactation. Systemic disease. Physical or mental disability. Non-restorable teeth. Any signs of resorption, immature roots, fracture, sinus tract and dental anomaly

Where it's running

• Al Azhar University
  Cairo, Nasr City, Egypt Recruiting

Study contacts

• Study coordinator: Sabah Morad Sobhy, PHD
• Email: sabamorad@yahoo.com
• Phone: +201096529143

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.