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Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Comparing two ultrasound-guided nerve blocks for pain after open kidney removal

Official title: Analgesic Efficacy of Ultrasound-Guided Serratus Intercostal Plane Block Versus Erector Spinae Plane Block for Postoperative Pain Control After Open Nephrectomy: A Prospective Randomized Controlled Trial

Run by Fayoum University Hospital · NCT07556536 · Data updated 2026-11-12

We will test whether a serratus intercostal plane block or an erector spinae plane block provides better pain relief for adults having open nephrectomy.

More Post Operative Pain trials

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment132 (estimated)
SponsorFayoum University Hospital
Academic / other
Locations1 site (Al Fayyum)
StatusRecruiting
StartedApril 10, 2026
Main results expectedMarch 1, 2027
Study endsJune 1, 2027
Registry record updatedApril 29, 2026
Trial IDNCT07556536 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–65 years with ASA physical status I–III who are scheduled for elective open nephrectomy via a flank incision are ideal candidates.

Probably not a fit

Patients on chronic opioid therapy, those with coagulation disorders, infection at the injection site, allergy to local anesthetics, or cognitive impairment affecting pain scoring are unlikely to benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blinded, randomized trial that will assign adults undergoing elective open nephrectomy to receive either a serratus intercostal plane block or an erector spinae plane block under ultrasound guidance after induction of general anesthesia. Group allocation is concealed and patients and outcome assessors are blinded, while the anesthesiologist who performs the block does not participate in postoperative assessments. All patients receive standardized general anesthesia, and blocks are performed before surgical incision with postoperative pain, opioid consumption, and complications recorded. The study follows local ethics approval and obtains written informed consent prior to randomization.

Why it matters

Potential benefit: If successful, the trial could identify a block technique that provides better postoperative pain control, reduces opioid use, and speeds recovery after open nephrectomy.

How similar studies have gone: Erector spinae plane blocks have shown beneficial analgesia for various thoracic and abdominal surgeries in prior reports, while serratus-intercostal plane blocks are less well studied specifically for open nephrectomy.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Patients scheduled for elective open nephrectomy under general anesthesia via flank incision .
2. Adult patients aged 18-65 years.
3. Patients with an American Society of Anesthesiologists (ASA) physical status I to III.

Exclusion Criteria:

1. Patient refusal.
2. Allergy to local anesthetics and patient with infection at the injection site of block.
3. Coagulation disorders or ongoing anticoagulant therapy.
4. Patients receiving opioids for chronic analgesic therapy (cancer, addiction).
5. Cognitive impairment preventing pain scoring.
6. Neurological or psychiatric disorders affecting pain assessment.

Where it's running

  • Fayoum university hospital
    Al Fayyum, Egypt     Recruiting

Study contacts

  • Principal investigator: Mohamed A Hamed, MD — faculty of medicine, fayoum university
  • Study coordinator: Hasnaa M Hashem, Master
  • Email: hm163@fayoum.edu.eg
  • Phone: 01064437956

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Post Operative Pain 71Open Nephrectomy 4Fayoum University Hospital 9
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.