Novel nanoparticle-enhanced disinfection for post-operative tooth pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial tests a novel nanoparticle disinfection protocol added to standard endodontic cleaning. It targets adults with type II diabetes who have mature maxillary front teeth and a baseline periapical lesion. The study aims to see if the nanoparticle approach can improve infection control in hard-to-reach canal areas and reduce post-treatment pain. The protocol builds on existing irrigants like NaOCl and EDTA by introducing Chitosan Nanoparticles as an antimicrobial and anti-biofilm agent. Outcomes will focus on safety and preliminary effectiveness in this specific dental setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diabetic patients type II of either gender aged from 18-40 years
* Permanent mature Maxillary anterior teeth having a baseline periapical lesion (PAI score ≥3).

Exclusion Criteria:

* Immuno-compromised patients.
* Pregnant women and smokers.
* Patients with a history of antibiotic or analgesics intake within the few days before the endodontic treatment.
* Teeth with root fractures or perforations.
* Teeth with lesions connected to adjacent teeth.

Where it's running

• Minia University, Faculty of Dentistry
  Minya, Egypt Recruiting

Study contacts

• Study coordinator: Ebthal Hamada Saleh, MSC
• Email: ebthalhamada9@gmail.com
• Phone: +201037570153

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.