Comparing dexmedetomidine and lignocaine for pain management in laparoscopic gallbladder surgery
Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy
This study is testing whether dexmedetomidine or lignocaine works better for managing pain and recovery in patients having laparoscopic gallbladder surgery.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | Sahiwal medical college sahiwal Government |
| Locations | 1 site (Sahiwal, Punjab Province) |
| Trial ID | NCT06740903 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the perioperative outcomes of dexmedetomidine versus lignocaine in patients undergoing laparoscopic cholecystectomy. A total of 140 patients will be randomly assigned to receive either dexmedetomidine or lignocaine infusion during surgery to assess their effects on postoperative pain, hemodynamic stability, and gastrointestinal function. The study will be conducted at Sahiwal Medical College over a 12-month period, with careful monitoring of vital signs and pain levels. The goal is to determine which medication provides better analgesia and fewer complications in this surgical setting.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 20-70 years undergoing elective laparoscopic cholecystectomy with ASA physical status I-II.
Not a fit: Patients with emergency surgery needs, significant comorbidities, or contraindications to the trial medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management and reduced complications for patients undergoing laparoscopic cholecystectomy.
How similar studies have performed: Previous studies have shown mixed results regarding the efficacy of dexmedetomidine and lignocaine for postoperative analgesia, making this investigation both relevant and necessary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients of age 20-70 years 2. Both gender 3. Laparoscopic cholecystectomy under general Anaesthesia 4. ASA I-II. Exclusion Criteria: * Emergency surgery * Patients with history of allergic reaction to trial drugs * Patients with cardiovascular disease, sickle cell disease, psychiatric disorder, peripheral vascular disease, and neurological diseases (on medical record) * Anemia * Patient on TCA or Beta blocker drugs. * Uncontrolled hypertension (P≥160/100 mmHg) * Uncontrolled diabetes mellitus * Obesity BMI \> 35
Where this trial is running
Sahiwal, Punjab Province
- Sahiwal Medical College Sahiwal — Sahiwal, Punjab Province, Pakistan (Recruiting)
Study contacts
- Study coordinator: Tallal Shahid, MBBS
- Email: tallalshahid@hotmail.com
- Phone: 00923215006215
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.