Comparing dexmedetomidine and lignocaine for pain management in laparoscopic gallbladder surgery
Official title: Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy
Run by Sahiwal medical college sahiwal · NCT06740903 · Data updated 2026-11-12
This study is testing whether dexmedetomidine or lignocaine works better for managing pain and recovery in patients having laparoscopic gallbladder surgery.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | Sahiwal medical college sahiwal Government |
| Locations | 1 site (Sahiwal, Punjab Province) |
| Status | Recruiting |
| Started | August 6, 2024 |
| Main results expected | August 6, 2025 |
| Study ends | September 6, 2025 |
| Registry record updated | December 18, 2024 |
| Trial ID | NCT06740903 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 20-70 years undergoing elective laparoscopic cholecystectomy with ASA physical status I-II.
✕Probably not a fit
Patients with emergency surgery needs, significant comorbidities, or contraindications to the trial medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the perioperative outcomes of dexmedetomidine versus lignocaine in patients undergoing laparoscopic cholecystectomy. A total of 140 patients will be randomly assigned to receive either dexmedetomidine or lignocaine infusion during surgery to assess their effects on postoperative pain, hemodynamic stability, and gastrointestinal function. The study will be conducted at Sahiwal Medical College over a 12-month period, with careful monitoring of vital signs and pain levels. The goal is to determine which medication provides better analgesia and fewer complications in this surgical setting.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management and reduced complications for patients undergoing laparoscopic cholecystectomy.
How similar studies have gone: Previous studies have shown mixed results regarding the efficacy of dexmedetomidine and lignocaine for postoperative analgesia, making this investigation both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients of age 20-70 years 2. Both gender 3. Laparoscopic cholecystectomy under general Anaesthesia 4. ASA I-II. Exclusion Criteria: * Emergency surgery * Patients with history of allergic reaction to trial drugs * Patients with cardiovascular disease, sickle cell disease, psychiatric disorder, peripheral vascular disease, and neurological diseases (on medical record) * Anemia * Patient on TCA or Beta blocker drugs. * Uncontrolled hypertension (P≥160/100 mmHg) * Uncontrolled diabetes mellitus * Obesity BMI \> 35
Where it's running
-
Sahiwal Medical College Sahiwal
Sahiwal, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Tallal Shahid, MBBS
- Email: tallalshahid@hotmail.com
- Phone: 00923215006215
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Magnesium given during colorectal cancer surgery to see if it lowers inflammation afterward
We’re testing whether giving magnesium sulfate during open colorectal cancer surgery can reduce postoperative inflammation in patients.
-
Novel nanoparticle-enhanced disinfection for post-operative tooth pain
A new nanoparticle-based disinfection method is being tested to see if it reduces pain after root canal treatment in adults with certain tooth infections.
-
Oral tizanidine before surgery to calm pain after leg surgery
This trial tests whether giving a preoperative dose of oral tizanidine helps reduce postoperative pain and improve sleep quality for adults undergoing lower limb orthopedic surgery.
-
Influence of Irrigant Delivery Methods on Postoperative Pain after Root Canal Treatment in Oval Canals
This trial tests whether different irrigant delivery and activation methods affect postoperative pain after primary root canal treatment in adults.
-
Effect of NeoSEALER FLO and AH Plus Sealer on Pain and Healing after Root Canal Treatment
This test compares NeoSEALER FLO and AH Plus sealer to see how they affect postoperative pain and healing of periapical lesions in mature permanent teeth.
-
ANTALGEEK Thess Monitoring for outpatient postoperative pain and recovery
This study tests whether using the ANTALGEEK Thess monitoring device at home, plus a fixed analgesia plan, helps manage acute postoperative pain in adults after outpatient surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.