Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Influence of Irrigant Delivery Methods on Postoperative Pain after Root Canal Treatment in Oval Canals

Official title: Influence of Irrigant Delivery Systems on the Incidence of Postoperative Discomfort in Oval Canals : A Randomized Clinical Trial

Run by Minia University · NCT07788027 · Data updated 2026-11-12

This trial tests whether different irrigant delivery and activation methods affect postoperative pain after primary root canal treatment in adults.

More Post Operative Pain trials

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment32 (estimated)
SponsorMinia University
Academic / other
Locations1 site (Minya)
StatusRecruiting
StartedApril 14, 2026
Main results expectedApril 1, 2027
Study endsApril 14, 2027
Registry record updatedAugust 26, 2026
Trial IDNCT07788027 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18-45 needing primary root canal treatment and in good general health (ASA-1) without recent analgesic or antibiotic use.

Probably not a fit

Patients with systemic conditions affecting pain or healing, pregnant or lactating women, or teeth with prior treatment or severe periodontal disease may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares how various irrigation delivery systems and activation methods influence postoperative discomfort in patients undergoing primary root canal treatment. The focus is on delivering sodium hypochlorite effectively to hard-to-reach areas of the root canal while minimizing irritants reaching surrounding tissues. It acknowledges anatomy-related challenges and potential pain outcomes associated with different activation techniques. The trial evaluates whether newer or more aggressive irrigation approaches increase or reduce postoperative pain compared with conventional methods.

Why it matters

Potential benefit: If successful, the approach could reduce postoperative pain and improve patient comfort after root canal therapy.

How similar studies have gone: Previous work shows irrigation activation can improve cleanliness but may not always reduce pain, making this assessment important.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Inclusion Criteria Patients aged between 18 and 45 years.
* Patients requiring primary root canal treatment.
* Patients in good general health..
* Subjects classified as ASA-1 following the classification proposed by the American Society of Anesthesiologists.

Exclusion Criteria:

* Patients with systemic diseases affecting pain perception or healing.
* Patients who had taken analgesics or antibiotics within 12-24 hours prior to treatment.
* Pregnant or lactating women.
* Previously treated teeth or teeth with root resorption, fractures, or severe periodontal disease. .

Where it's running

  • Endodontics Department Faculty of Dentistry
    Minya, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.