Pulpotomy versus root canal for painful lower premolars and molars
Official title: Evaluation of the Outcomes of Total Pulpotomy, Radicular Pulpotomy, and Root Canal Treatment in Teeth With Extremely Deep Caries and Symptomatic Irreversible Pulpitis
Run by Mustafa Kemal University · NCT07375576 · Data updated 2026-11-12
This study will see if total pulpotomy, radicular pulpotomy, or root canal treatment best controls postoperative pain and leads to successful outcomes for people aged 15–45 with symptomatic irreversible pulpitis in mandibular premolars and molars.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 99 (estimated) |
| Sponsor | Mustafa Kemal University Academic / other |
| Locations | 1 site (Hatay, Antakya) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | April 1, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT07375576 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy people aged 15–45 with restorable mandibular first or second molars or premolars diagnosed with symptomatic irreversible pulpitis, healthy periodontal status (pocket ≤ 3 mm), and no periapical radiolucency.
✕Probably not a fit
Patients with cracked or fractured teeth, subgingival caries, periapical radiolucency, non-restorable teeth, or relevant systemic disease are unlikely to benefit from inclusion in this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Ninety-nine mandibular premolars and molars with symptomatic irreversible pulpitis will be randomized equally to total pulpotomy, radicular pulpotomy, or conventional root canal treatment. Treatments are delivered under local anesthesia with rubber dam isolation and standardized protocols, including MTA placement for pulpotomy and conventional endodontic protocols for RCT. Hemostasis for pulpotomies is achieved with 2.5% NaOCl and the time to hemostasis is recorded; caries removal and access are standardized across groups. Primary outcomes include postoperative pain control and clinical/radiographic treatment success over the follow-up period.
Why it matters
Potential benefit: If successful, less invasive pulpotomy options could provide faster, simpler treatment with good pain control and tooth preservation compared with conventional root canal therapy.
How similar studies have gone: Recent clinical reports and trials have shown promising short- and medium-term success for pulpotomy in irreversible pulpitis, but long-term equivalence to root canal therapy is still being established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy patients of both sexes, aged between 15 and 45 years, with no systemic diseases, will be screened for inclusion in the study. Strict eligibility criteria will be applied. The patients included in the study must have restorable, extremely deep carious lesions in the mandibular first and second molars, and first and second premolars; healthy periodontal status (periodontal pocket ≤ 3 mm); and a clinical diagnosis of symptomatic irreversible pulpitis (history of spontaneous pain, pain persisting after removal of the stimulus, exaggerated and prolonged response to cold testing, and a positive response to the electric pulp test). Exclusion Criteria: * Teeth with cracks or cusp fractures, subgingival caries, or periapical radiolucency will not be included in the study. Informed consent will be obtained from all included patients.
Where it's running
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Department of Endodontics, Faculty of Dentistry, Hatay Mustafa Kemal University
Hatay, Antakya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Efkan Aksay
- Email: efkanaksay@gmail.com
- Phone: +905062654889
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.