Lidocaine versus lidocaine plus dexmedetomidine for IV regional anesthesia in upper limb surgery
Comparison of Lidocaine Alone Versus Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA)
This trial will test whether adding dexmedetomidine to lidocaine for intravenous regional anesthesia gives better pain relief and longer-lasting analgesia for adults having elective upper limb surgery under 45 minutes.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Fatima Memorial Hospital Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Trial ID | NCT07034300 on ClinicalTrials.gov |
What this trial studies
Participants undergoing elective upper limb surgery under 45 minutes receive intravenous regional anesthesia with a pneumatic tourniquet and injection of local anesthetic into the isolated limb. One group will receive lidocaine alone and the other will receive lidocaine combined with dexmedetomidine. Pain scores, duration of analgesia, and tourniquet-related discomfort will be recorded to compare the two approaches. Patients must be ASA I–II and meet exclusion criteria such as sleep apnea, BMI over 30, heart block, or uncontrolled hypertension.
Who should consider this trial
Good fit: Ideal candidates are adults scheduled for elective upper limb surgery under 45 minutes who are ASA physical status I–II and do not have sleep apnea, BMI >30, heart block, or uncontrolled hypertension.
Not a fit: Patients with sleep apnea, BMI over 30, heart block, uncontrolled hypertension, or those needing longer or different types of surgery are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, adding dexmedetomidine could provide longer postoperative pain relief and reduce intraoperative tourniquet discomfort.
How similar studies have performed: Previous trials of adding dexmedetomidine or other alpha-2 agonists to regional anesthetics have often shown prolonged analgesia and reduced opioid needs, though results and side-effect profiles have varied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiology Status I * American Society of Anesthesiology Status II * Elective surgery * Surgery duration \<45 minutes Exclusion Criteria: * Sleep apnea * BMI \>30 * Heart block * uncontrolled hypertension
Where this trial is running
Lahore, Punjab Province
- Department of Anesthesiology, Fatima Memorial Hospital — Lahore, Punjab Province, Pakistan (Recruiting)
Study contacts
- Principal investigator: Muhammad M Younas, MBBS — Fatima Memorial Hospital
- Study coordinator: Muhammad M Younas, MBBS
- Email: mansoor.gujjar344@gmail.com
- Phone: +923441346810
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.