Effect of NeoSEALER FLO and AH Plus Sealer on Pain and Healing after Root Canal Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study examines how two root canal sealers—NeoSEALER FLO, a bioceramic sealer, and AH Plus, an epoxy resin-based sealer—influence postoperative pain and periapical healing. Eligible participants have apical periodontitis in maxillary anterior teeth and are free of systemic diseases that could affect healing. The trial focuses on instrument cleaning, irrigation, and sealer application to achieve a tight root canal seal and promote repair. Outcomes include pain levels and radiographic or clinical signs of healing monitored over a 1-year follow-up. The study is conducted at Minia University with adult participants who meet the inclusion criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with mature permanent teeth.
* Patients with apical periodontitis.
* Maxillary anterior teeth only will be involved.
* Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
* Patients who will agree to the consent and will commit to follow-up period.
* The selected teeth should have periapical lesion score ≤3

Exclusion Criteria:

* Patients with immature canals.
* Patients with swelling.
* Pregnant females.
* Patients who could/would not participate in a 1-year follow-up.
* Geriatric patients.
* Patients with old age.
* Teeth with periodontal involvement.
* Teeth with vertical root fractures.
* Non-restorable teeth.
* cases with previously initiated endodontic treatment.

Where it's running

• Minia University, Faculty of Dentistry
  Minya, Egypt Recruiting

Study contacts

• Study coordinator: Allaa Mohamed Kamel Mohamed, MSC
• Email: allaa91mk@gmail.com
• Phone: +201006767773

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.