Registry tracking outcomes of cryoanalgesia for post-operative pain management
Official title: The CryoICE™ Cryoanalgesia Registry for Pain Management in Post-cardiothoracic Surgery Via Cryoablation of the Intercostal Nerves
Run by AtriCure, Inc. · NCT05110989 · Data updated 2026-11-12
This study is tracking how well a new pain management technique using cryoablation of nerve blocks works for patients after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | AtriCure, Inc. Industry-sponsored |
| Locations | 11 sites (Jacksonville, Florida and 10 other locations) |
| Status | Recruiting |
| Started | June 29, 2018 |
| Main results expected | January 2035 |
| Study ends | January 2040 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT05110989 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients aged 12 and older who are scheduled for or have undergone cryoablation of the intercostal nerves.
✕Probably not a fit
Patients currently enrolled in other trials that may affect their treatment or those with specific exclusion criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational registry collects data on patients who have undergone cryoablation of the intercostal nerves to manage post-operative pain. It includes both retrospective and prospective data collection to evaluate the effectiveness and outcomes associated with the AtriCure Cryo Nerve Block device. The study aims to provide insights into the benefits and potential complications of this pain management technique across multiple healthcare facilities.
Why it matters
Potential benefit: If successful, this registry could enhance understanding of cryoanalgesia's effectiveness in managing post-operative pain, leading to improved patient care.
How similar studies have gone: While this approach is observational, similar studies on nerve block techniques have shown promising outcomes in pain management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients whose age is 12 years or above, and are able to give informed consent/assent specific to state and national law. 2. Patients have been scheduled by physician(s) to undergo or have undergone cryoablation of the intercostal nerves utilizing at least one AtriCure device or are similar patients treated without the use of cryoablation Exclusion Criteria: 1. Patient is enrolled in a concurrent trial that may impact the treatment offered by the registry devices. 2. Patient with exclusion criteria required by local governance. 3. Women of childbearing potential who are, or plan to become, pregnant during the time of the study
Where it's running
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Baptist MD Anderson Cancer Center
Jacksonville, Florida, United States Recruiting -
AdventHealth
Orlando, Florida, United States Recruiting -
Luminis Health Anne Arundel Medical Center
Annapolis, Maryland, United States Recruiting -
Elliot Hospital
Manchester, New Hampshire, United States Recruiting -
The Christ Hospital
Cincinnati, Ohio, United States Recruiting -
Baylor College of Medicine
Houston, Texas, United States Recruiting
Show 5 more locations
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Medical University of Vienna
Vienna, Austria Recruiting -
UZ Leuven
Leuven, Belgium Recruiting -
University of Heidelberg
Heidelberg, Germany Recruiting -
University Hospitals Leicester NHS Trust
Leicester, United Kingdom Recruiting -
St. Luke's Hospital of Kansas City
Kansas City, Missouri, United States Completed
Study contacts
- Principal investigator: Curits Quinn, MD — Elliot Hospital
- Study coordinator: Elizabeth Menard
- Email: REDUCE-REGISTRY@atricure.com
- Phone: 8327120715
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.