Comparing nerve block and morphine for pain relief after hip surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of a pericapsular nerve block (PENG) against intrathecal morphine for managing postoperative pain in patients undergoing total hip arthroplasty. Participants will be randomly assigned to receive either the PENG block or intrathecal morphine, with both groups receiving spinal anesthesia. The study will evaluate pain scores, morphine consumption, and any related side effects to determine if the PENG block provides equivalent analgesia to morphine. A total of 80 patients will be enrolled in this double-blind, non-inferiority trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female patients
* ASA (American Society of Anaesthesiologists) I-III
* 18 years of age or older
* Patients scheduled for elective primary hip arthroplasty
* Able to give written conformed consent autonomously

Exclusion Criteria:

* Refusal or inability to give consent
* Allergy to any of: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine, ondansetron or dexamethasone
* Bleeding diathesis
* Neurological deficit of the operative side
* Existing preoperative opioid use
* Renal insufficiency (GFR\<30ml/min according to the Cockroft-Gault formula)
* Hepatic insufficiency
* Pregnant or lactating women

Where it's running

• University Hospital of Lausanne
  Lausanne, Canton of Vaud, Switzerland Recruiting

Study contacts

• Study coordinator: Eric Albrecht, Prof
• Email: eric.albrecht@chuv.ch
• Phone: +41795566341

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.