Condition

Cardiac Disease clinical trials and research

• 29Clinical trials
• 15NIH research projects
• 21Countries

Newest Cardiac Disease clinical trials

All recruiting trials (29)

• Remote Balance in Everyday Life for young MI patients with distress

  This study tests a remote 6-session program (rBEL) to help adults under 55 who had a heart attack and feel distressed see if the program and study procedures are feasible.

  Recruiting Uppsala University · Uppsala · NCT07706816

• Well-being program for caregivers of patients with advanced heart or lung disease

  This study tests an 8-week, home-based wellness program delivered virtually to caregivers of people with advanced cardiac or pulmonary disease to see if it’s feasible and acceptable.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07685912

• Digital diagnosis of newborn heart sounds

  This project will test a digital, machine-learning tool that listens to newborn heart sounds to try to detect serious congenital heart problems in the first month of life.

  Recruiting at 4 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO and 4 other locations · NCT07542509

• Efferon LPS hemoadsorption during and after heart surgery

  This trial tests whether using the Efferon® LPS filter during cardiopulmonary bypass and again within 24 hours afterward can lower the chance and severity of multiple organ dysfunction in adults having cardiac surgery who are at higher surgical risk.

  Recruiting at 3 sites Efferon JSC · Barnaul and 2 other locations · NCT07532174

• Comparing preoperative cardiac clearance with the G60 Orthopedic Hip Frailty Index to predict outcomes after hip fracture surgery

  This project will test whether preoperative cardiac clearance predicts short-term postoperative mortality better than the G60 Orthopedic Hip Frailty Index for people aged 60 and older who need surgical treatment for hip fractures.

  Recruiting Methodist Health System · Dallas, Texas · NCT07490184

• Ask Questions About Clinical Trials: A Tool to Help Patients Discuss Trials

  This study tests a patient-friendly brochure called the ASQ-CT to see if it helps adults with cancer, heart disease, or neurologic conditions talk with their providers about clinical trials.

  Recruiting at 8 sites Barbara Ann Karmanos Cancer Institute · Bay City, Michigan and 7 other locations · NCT07343297

• Deep learning reconstruction for clearer cardiac MRI scans

  This project tests whether AI-based MRI sequences produce better heart images for adults who need a cardiac MRI.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07274436

• Left bundle branch area pacing with Tendril STS or UltiPace leads

  This study will try left bundle branch area pacing with the Tendril STS or UltiPace lead in adults who need pacemaker leads for bradycardia or related heart conditions to see if pacing and sensing are safe and work through six months after implant.

  Recruiting at 13 sites Abbott Medical Devices · Rio de Janeiro, Rio de Janeiro and 14 other locations · NCT07217392

• FEIBA versus fresh frozen plasma as first-line treatment for bleeding after cardiac surgery

  This Phase 2 trial will test whether FEIBA works better than fresh frozen plasma (FFP) as the first treatment for adults who develop coagulopathic microvascular bleeding after non-emergency cardiac surgery with cardiopulmonary bypass.

  Recruiting Phase 2 Northwell Health · Manhasset, New York · NCT07032792

• Gene testing for diagnosing and treating heart disease

  This study is trying to see if gene testing can help doctors better diagnose and treat heart conditions related to arrhythmias in patients at the Cardiogenetic Center in Italy.

  Recruiting University Hospital of Ferrara · Ferrara · NCT06898307

• Assessing cardiovascular and brain interactions in healthy adults

  This study tests how the heart and brain work together in healthy adults to see if there’s a link between physical and mental health.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milano · NCT06785181

• Investigating heart problems in patients with fatty liver disease

  This study looks at how fatty liver disease might affect heart health in adults aged 18-65 by checking for heart problems like coronary artery disease and heart failure.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh, Chandigarh · NCT06386094

• Measuring how the brain, autonomic system, and blood vessels interact

  This project tests new mathematical and monitoring methods to measure how brain activity, autonomic function, and blood flow interact in adults scheduled for major heart surgery, with the goal of linking these patterns to depression and cardiac outcomes.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT06294119

• Comparing high and low dose pain relief methods after heart valve surgery

  This study is testing whether a high or low dose of a new pain relief method can help patients after heart valve surgery feel less pain and use fewer opioids.

  Recruiting Jessa Hospital · Hasselt, Limburg · NCT06205875

• One-year comparison of radial artery versus no-touch saphenous vein grafts in women having coronary bypass surgery

  This test compares whether a radial artery graft or a 'no-touch' saphenous vein graft stays open better for one year in women undergoing coronary bypass surgery.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06179329

• Colchicine's effect on inflammation during cardiac surgery

  This study is testing if colchicine can help reduce inflammation and improve recovery for people aged 50 to 80 who are having heart surgery.

  Recruiting Phase 3 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06118034

• Registry for tracking neurodevelopment in children with congenital heart disease

  This study is creating a national registry to track the development of young children with serious heart defects who have heart surgery early in life, to see how their health and treatments affect their growth and learning as they get older.

  Recruiting at 3 sites University Children's Hospital, Zurich · Bern and 2 other locations · NCT05996211

• Validation of advanced cardiac MRI technology

  This study is testing a new, faster way to take heart images without radiation to see if it can help doctors better understand heart function and structure.

  Recruiting University Hospital, Bordeaux · Pessac · NCT05877755

• Using a nerve block to manage pain after heart surgery

  This study tests if a nerve block can help heart surgery patients feel less pain and use fewer painkillers after their operation.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT05833048

• Using AI to detect heart rhythm disorders from ECGs

  This study is testing a new AI tool that looks at ECGs to see if it can better identify types of Long QT syndrome and the risk of dangerous heart rhythms for patients.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05829993

• Predicting brain complications after heart surgery

  This study is testing two ways to measure how well the brain controls blood flow during heart surgery to see if it can help predict the risk of complications like strokes afterward.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT05786274

• Using colchicine and ticagrelor to prevent ischemic stroke in patients with atherosclerosis

  This study is testing if a combination of low-dose colchicine and ticagrelor can help prevent future strokes in people with atherosclerosis who have already had an ischemic stroke.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT05476991

• Observational study on drug use in critically ill children

  This study looks at how different medications work in critically ill children in the Pediatric Cardiac Intensive Care Unit to better understand their effects and safety.

  Recruiting Duke University · Durham, North Carolina · NCT05055830

• Registry for monitoring cardiac device performance and safety

  This study is collecting information on how well Boston Scientific heart devices work and their safety for patients who have recently had procedures with these devices.

  Recruiting at 24 sites Boston Scientific Corporation · Jette and 25 other locations · NCT04823663

• Using parathyroid hormone to treat bone disorder in kidney disease patients

  This study is testing whether a hormone treatment can help improve bone health and reduce fracture risk in patients with chronic kidney disease.

  Recruiting Phase 4 Herlev Hospital · Aalborg and 3 other locations · NCT04522622

• Monitoring long-term effects of SARS-CoV-2 infections

  This study follows patients who were hospitalized with COVID-19 to see how the virus has affected their lungs and heart over the long term.

  Recruiting University of Giessen · Giessen · NCT04442789

• Registry for patients referred to cardio-oncology

  This study is collecting information from cancer patients who are referred for heart health checks to see how cancer treatments might affect their hearts.

  Recruiting European Georges Pompidou Hospital · Paris · NCT04407780

• Comparing Heparin and Placebo in Patients Undergoing Cardiac Catheterization

  This study is testing whether different doses of heparin can help prevent complications like bruising and artery blockage in patients getting a heart procedure through their wrist.

  Recruiting at 2 sites Phase 3 London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Hamilton, Ontario and 1 other locations · NCT04374799

• Using fresh autologous blood transfusion after heart surgery

  This study tests if giving patients their own fresh blood after heart surgery can help them lose less blood and recover better compared to standard treatment.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03204357

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Four-Chamber Echo Insights to Improve Cardiac Diagnosis

  A new AI-based approach uses routine echocardiograms to map the heart’s four chambers and flow patterns, helping doctors diagnose acute heart conditions more accurately.

  NIH research Washington University · Saint Louis, United States · NIH-11578689

• Diabetes-related gut imbalance and heart disease in diabetes patients

  A study to understand how changes in gut bacteria caused by diabetes may raise the risk of heart disease and to explore ways to prevent it.

  NIH research Georgia State University · Atlanta, United States · NIH-11381740

• Peripheral nervous system targets to reduce heart rhythm problems in high blood pressure and heart failure

  A research project looks at how the nerves outside the brain influence dangerous heart rhythms in people with high blood pressure and heart failure, with the goal of finding new ways to reduce these risks.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11325468

• How immune cells drive heart inflammation and repair

  This project aims to find ways to calm overactive immune cells in people with heart injury or heart failure so the heart can heal with less scarring.

  NIH research Northwestern University · Chicago, United States · NIH-11264929

• Understanding heart disease in PGM1‑CDG

  This project looks at how PGM1‑CDG causes weakening of the heart muscle in people with PGM1‑CDG using mouse heart models and patient tissue.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11231670

• Understanding Heart Disease in Type 1 Diabetes

  This research explores new ways to protect the heart from damage in people with type 1 diabetes, focusing on natural body chemicals called Substance P.

  NIH research West Virginia University · Morgantown, United States · NIH-11194459

• Understanding how nerve activity affects heart disease

  This study is looking at how nerve activity affects heart problems like high blood pressure and heart failure, with the goal of finding new ways to prevent dangerous heart rhythms and help patients feel better.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11132949

• How diabetes-related changes in gut bacteria affect the heart

  Looks at whether diabetes-related changes in gut bacteria allow bacteria or their products to leak into the body and harm the heart in people with diabetes.

  NIH research Georgia State University · Atlanta, United States · NIH-11118800

• Understanding heart issues after severe COVID-19

  This project looks at how the immune system might cause heart problems in people who had severe COVID-19.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11110480

• Investigating how certain proteins affect heart disease in people with type 1 diabetes

  This study is looking at how a protein called substance P might help protect the hearts of people with type 1 diabetes, and it hopes to find new ways to prevent or improve heart problems related to the condition.

  NIH research West Virginia University · Morgantown, United States · NIH-11074273

• Understanding how immune cells affect heart inflammation and disease

  This study is looking at how certain immune cells in the heart can cause inflammation and contribute to heart problems, and it aims to find ways to reduce their activity to help improve heart health for people with heart conditions.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11037601

• Investigating heart disease mechanisms in patients with PGM1-CDG

  This study is looking at how a lack of a specific enzyme called PGM1 can cause heart problems, especially a condition called dilated cardiomyopathy, and it hopes to find new treatments that could help patients with this condition.

  NIH research University of Utah · Salt Lake City, United States · NIH-10991821

• Understanding how heart conditions contribute to strokes

  This study is looking at how certain heart problems might affect recovery after a stroke, and it's for people who have had an acute ischemic stroke to help improve their care and outcomes.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10897041

• How diabetes affects gut bacteria and heart disease

  This study is looking at how changes in gut bacteria from diabetes might increase the risk of heart disease, even if blood sugar levels are normal, and it hopes to find new ways to help prevent heart problems for people with diabetes.

  NIH research Georgia State University · Atlanta, United States · NIH-10874429

• Developing a platform to predict heart disease risk in boys with Duchenne muscular dystrophy

  This study is looking at how heart disease develops in boys with Duchenne muscular dystrophy (DMD) to help figure out who might be at greater risk for heart problems, so that doctors can provide better treatments and care.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10795634

Related topics

Quick answers

How many Cardiac Disease clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in Italy (7 trials), France (6 trials), United States (6 trials), Germany (3 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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