How obesity affects blood pressure and insulin resistance in women with Polycystic Ovary Syndrome
Official title: Role of obesity in blood pressure regulation and insulin resistance in Polycystic Ovary Syndrome
Funded at University of Mississippi Med Ctr · NIH-10991667 · Data updated 2026-11-12
This study is looking at how being overweight, blood pressure, and insulin levels are connected in women with Polycystic Ovary Syndrome (PCOS), and it hopes to find new ways to help manage heart health for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $600,809 |
| NIH project number | 5R01HL171494-02 |
| Project ID | NIH-10991667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who have been diagnosed with Polycystic Ovary Syndrome and exhibit symptoms such as obesity and insulin resistance.
✕Less likely to help
Patients who do not have Polycystic Ovary Syndrome or those without obesity or insulin resistance may not benefit from this research.
What this research studies
This research investigates the relationship between obesity, blood pressure regulation, and insulin resistance in women diagnosed with Polycystic Ovary Syndrome (PCOS). The study aims to understand how the Renin-Angiotensin System (RAS) in adipose tissue influences these conditions. By examining the roles of androgens, adiposity, and adiponectin, the research seeks to identify potential therapeutic targets for managing cardiovascular risk factors in PCOS. Patients may be involved in assessments that explore these interactions and their effects on health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage cardiovascular risk factors in women with PCOS.
How similar studies have gone: Previous research has shown promising results in understanding the role of the Renin-Angiotensin System in metabolic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Yanes Cardozo, Licy Lorena — University of Mississippi Med Ctr
- Study coordinator: Yanes Cardozo, Licy Lorena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.