Exercise and diet to reduce eye dryness in women with PCOS and obesity
PCOS and Problem of Eye Dryness: Is There a Benefit From Lifetyle Changes in Obese Women
We will test whether adding regular treadmill walking to metformin and a low-calorie diet helps reduce eye dryness in obese women with PCOS.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 30 Years to 40 Years |
| Sex | Female |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Giza, Dokki) |
| Trial ID | NCT07366944 on ClinicalTrials.gov |
What this trial studies
Forty women with PCOS, class I obesity, and bilateral dry eye will be assigned to two groups of 20. Both groups will receive metformin three times daily and follow a low-calorie diet for 12 weeks. One group will additionally perform one hour of treadmill walking three times per week for 12 weeks. Eye dryness symptoms and clinical measures will be monitored over the study period to compare outcomes between the groups.
Who should consider this trial
Good fit: Women with PCOS who have class I obesity and bilateral dry eye and who can safely exercise and take metformin are ideal candidates.
Not a fit: Women with significant liver, cardiac, or renal disease, those who are not obese or do not have dry eye, or who cannot exercise safely are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, adding regular walking to diet and metformin could reduce dry eye symptoms and improve weight and metabolic health in these women.
How similar studies have performed: Lifestyle changes and metformin have shown benefits for metabolic and reproductive outcomes in PCOS in prior studies, but their specific effect on eye dryness has been little studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * PCOS women * obese class I * bilateral dryness of eye Exclusion Criteria: * liver disoease * cardiac disease * renal disease
Where this trial is running
Giza, Dokki
- Cairo University — Giza, Dokki, Egypt (Recruiting)
Study contacts
- Principal investigator: Ali MA Ismail, lecturer — Cairo University
- Study coordinator: Ali MA Ismail, lecturer
- Email: ali.mohamed@pt.cu.edu.eg
- Phone: 01005154209
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.