Semaglutide to help restore monthly ovulation in teens and adults with PCOS
Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome
This project gives semaglutide to teens and adults with polycystic ovary syndrome (PCOS) to help with weight, insulin control, and return to regular ovulation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11188966 on NIH RePORTER |
What this research studies
If you have PCOS and struggle with irregular or absent periods, researchers will give semaglutide and follow you over time to track menstrual cycles, hormones, weight, and blood sugar responses. The team will measure insulin sensitivity, post-meal glucose, testosterone, and whether ovulation resumes after treatment. The trial enrolls both adolescents and adults and expands on an initial short pilot that showed metabolic improvements with oral semaglutide. Visits will include blood tests, menstrual tracking, and in-person clinic appointments.
Who could benefit from this research
Good fit: Ideal candidates are adolescents and adults with a diagnosis of PCOS, especially those with obesity or insulin resistance and irregular or absent menstrual cycles, who can attend clinic visits in Aurora, Colorado.
Not a fit: People without PCOS, those who are pregnant or planning pregnancy, those with contraindications to GLP-1 receptor agonists, or those unwilling/unable to attend regular clinic visits may not benefit or be eligible.
Why it matters
Potential benefit: If successful, semaglutide could restore regular ovulation and improve menstrual health, metabolic control, and weight for people with PCOS.
How similar studies have performed: Smaller trials of older GLP-1 drugs like liraglutide and exenatide showed improved menstrual frequency and lower testosterone, and a short semaglutide pilot in adolescents improved metabolic measures but did not yet confirm ovulation restoration.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Cree, Melanie G — University of Colorado Denver
- Study coordinator: Cree, Melanie G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.