Condition

Depression, Anxiety clinical trials and research

• 37Clinical trials
• 3NIH research projects
• 11Countries

Newest Depression, Anxiety clinical trials

All recruiting trials (37)

• Helping children and teens manage severe irritability, anxiety, and depression.

  This program will try cognitive behavioral therapy plus detailed behavioral and brain tests to see if it helps children and teens (ages 4–17) with severe irritability, anxiety, or depression.

  Recruiting Florida State University · Tallahassee, Florida · NCT07296939

• How symptoms, thoughts, and behaviors change week by week during a 7-week online mindfulness program for emotional distress

  This trial tests whether a 7-week self-guided online mindfulness program helps people with high emotional distress (such as depression or anxiety) and tracks weekly changes in their emotions, thoughts, and behaviors.

  Recruiting Peking University · Beijing · NCT07280481

• Comparing support options for the Healthy Minds meditation app

  This study tests whether adding a brief coaching session, on-demand email help, or short microsupport messages helps adults with elevated depression or anxiety get more benefit from the Healthy Minds meditation app.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07278466

• Peer support to expand access to Spanish digital cognitive behavioral therapy in the Mission community

  This project will test whether adding peer support helps Spanish-speaking Latino adults in the Mission neighborhood use a Spanish-language online CBT program to reduce symptoms of depression or anxiety.

  Recruiting University of California, Berkeley · San Francisco, California · NCT07186816

• Rapid screening for anxiety and depression in children, teens, and young adults treated for cancer

  This study tests a short questionnaire to quickly find anxiety or depression in children, adolescents, and young adults who were treated for cancer.

  Recruiting at 4 sites Centre Hospitalier Universitaire de Saint Etienne · Angers and 6 other locations · NCT07117058

• Building Connections: improving cancer screening, weight management, and mental health for adults in vulnerable communities

  This program will try to improve cancer screening, weight management, and mental health care for adults served by community clinics in Massachusetts.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07091032

• A sleep-health program to help teens recover faster from concussion

  This project tests whether a personalized, multidimensional sleep-health program helps adolescents (ages 10–19) recover faster from concussion and sleep better than standard guidance.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07082218

• Cognitive behavioral therapy plus mindfulness program to help people adjust to vision loss

  This project will try an 8-week group program combining cognitive behavioral therapy and mindfulness for adults adjusting to vision loss.

  Recruiting The Chicago Lighthouse · Chicago, Illinois · NCT07073521

• Which factors shape EMDR outcomes for depressive symptoms

  See if patient and therapist characteristics predict how well EMDR helps adults in Italy who have depression, anxiety, post-traumatic stress, or dissociative symptoms.

  Recruiting University of Turin, Italy · Turin, Turin · NCT07033741

• How sitting habits relate to depressive symptoms

  This trial will test whether a physical activity program that reduces passive sitting (like TV time) helps adults over 17 with mild to severe depressive symptoms feel better.

  Recruiting at 2 sites University of Sao Paulo General Hospital · São Paulo, SO and 1 other locations · NCT07007234

• Training behavioral health technicians to improve mental health support for military personnel

  This study is testing whether giving special training to behavioral health technicians can help active-duty airmen feel better and manage stress more effectively compared to those who get care from untrained technicians.

  Recruiting New York University · New York, New York · NCT06981598

• Single-session intervention to change ambiguity aversion

  This trial tests whether one brief intervention can change how adults with intolerance of uncertainty and anxiety make ambiguous decisions and how their brains respond.

  Recruiting Northwestern University · Chicago, Illinois · NCT06962527

• Nature-based therapy for depression and anxiety

  This study is testing whether outdoor therapy sessions that encourage physical activity in nature can help people with depression and anxiety feel better compared to those who receive regular care.

  Recruiting Phase 2 Kansas State University · Manhattan, Kansas · NCT06858189

• Using technology to prevent suicide among youth in Colombia

  This study is testing a new technology-based program to help reduce suicidal thoughts and behaviors among young people in Colombian schools.

  Recruiting Brown University · Bogotá, Colombia · NCT06651554

• Rehabilitation for stroke patients using nature-based therapies

  This study tests if nature-based rehabilitation can help people who have recently had a stroke recover better than those who only do light physical activity.

  Recruiting Joint Authority for Päijät-Häme Social and Health Care · Lahti · NCT06633146

• Improving mental health care for pregnant women with mood and anxiety disorders

  This study is testing a new way to help pregnant women in Kenya who have mood and anxiety disorders by providing better screening and treatment through their regular health care visits.

  Recruiting at 2 sites Kenyatta National Hospital · Nairobi and 1 other locations · NCT06456307

• A program to improve emotional awareness and mental health in parents of young children

  This study tests a new program that helps parents of young children with depression and anxiety feel better and improve their parenting skills.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT06455397

• Internet-based interventions for cardiac arrest survivors

  This study tests whether a web app that offers lifestyle support can help people who survived a cardiac arrest feel less anxious and depressed, and improve their overall quality of life.

  Recruiting at 2 sites Azienda Usl di Bologna · Bologna, Bologna and 1 other locations · NCT06395558

• Exploring new brain stimulation targets for mental health conditions

  This study is testing how a brain stimulation treatment can help people with depression, anxiety, OCD, and schizophrenia by looking at changes in their brain and behavior.

  Recruiting Phase 2 Brigham and Women's Hospital · Sunnyvale, California and 1 other locations · NCT06376734

• Impact of long-term benzodiazepine use on cognitive function

  This study is trying to see how long-term use of benzodiazepines affects thinking and brain health in people who have taken them for at least three months compared to those who haven't.

  Recruiting The First Affiliated Hospital of Dalian Medical University · Dalian, Liaoning · NCT06250842

• Improving HIV prevention for pregnant women in Zimbabwe

  This study is trying to improve how pregnant women in Zimbabwe can use a medicine to prevent HIV by addressing the challenges they face and getting feedback from them and their healthcare providers.

  Recruiting Massachusetts General Hospital · Harare · NCT06226155

• Psilocybin-assisted therapy for anxiety and depression in advanced cancer patients

  This study is testing if therapy combined with psilocybin can help advanced cancer patients who are feeling anxious or depressed feel better and improve their quality of life.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06200155

• Using brain stimulation and medication to help young people with suicidal thoughts

  This study is testing if a combination of brain stimulation and a medication can help young adults aged 18-24 who have serious thoughts of suicide feel better.

  Recruiting Phase 2 University of Calgary · Calgary, Alberta · NCT06121284

• Improving mental health support for teachers and caregivers in Uganda

  This study is testing a new mobile app designed to help teachers and caregivers in Uganda improve their mental health and see if it makes a difference compared to those who don’t use it.

  Recruiting at 2 sites NYU Langone Health · Kampala and 1 other locations · NCT06087159

• Lifestyle medicine program to help rural adults with multiple chronic conditions

  This program will try supervised exercise and lifestyle coaching for rural adults aged 18–64 who have two or more chronic conditions to see if access to a wellness facility improves their health.

  Recruiting West Virginia School of Osteopathic Medicine · Lewisburg, West Virginia · NCT06049420

• Investigating brain responses to threats in anxiety and depression

  This study is testing how an anti-anxiety medication affects the brain's response to threats in people with anxiety, depression, or both to better understand their differences and improve treatments.

  Recruiting Phase 4 Laureate Institute for Brain Research, Inc. · Tulsa, Oklahoma · NCT06004115

• Using Magnesium and Vitamin B6 to Treat First Episode Bipolar Disorder

  This study is testing if adding magnesium and vitamin B6 to standard treatment can help people who are having their first episode of bipolar disorder feel better and recover more effectively.

  Recruiting Phase 2 Mclean Hospital · Belmont, Massachusetts · NCT05837104

• Community-based mental health support in Harlem

  This study is testing a new way to improve mental health support in Harlem by training community health workers and connecting them with local organizations to see if it helps people get better care.

  Recruiting at 2 sites City University of New York, School of Public Health · New York, New York and 1 other locations · NCT05833555

• Examining mental health issues in endurance athletes

  This study looks at how common mental health issues like depression and anxiety are among endurance athletes, such as marathon runners and triathletes, to better understand their experiences.

  Recruiting Ultra Sports Science Foundation · Pierre-Bénite · NCT05768841

• Using Acceptance and Commitment Therapy to help Black adolescents cope with race-related stress

  This study is testing whether Acceptance and Commitment Therapy can help Black teenagers cope better with stress, anxiety, and depression related to race-related challenges.

  Recruiting Phase 1/2 Children's Hospital Los Angeles · Los Angeles, California · NCT05685368

• Training therapists to provide evidence-based therapies for cancer patients

  This study is testing whether training therapists to provide personalized therapy can help cancer patients manage their stress and improve their overall well-being during treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05674357

• Using music therapy to improve mental health

  This study is testing if music therapy can help people with depression and anxiety feel better by comparing those who receive therapy to those who wait for it.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT05648539

• Improving concussion recovery with high dose exercise

  This study is testing if a special exercise program can help teenagers recover faster from concussions and feel better sooner.

  Recruiting at 3 sites Phase 1/2 University of Colorado, Denver · Aurora, Colorado and 2 other locations · NCT05434130

• Improving mental health for Hispanic adolescents in primary care

  This study is testing a new online program called Familias Unidas to see if it can help Hispanic teens aged 12 to 16 feel less depressed, anxious, and suicidal while getting support from their families.

  Recruiting at 6 sites University of Miami · Miami, Florida and 16 other locations · NCT05426057

• Impact of Duavive on mood and anxiety in menopausal women

  This study is testing if a new hormone treatment can help improve mood and reduce anxiety in women going through menopause.

  Recruiting Phase 1 St. Joseph's Healthcare Hamilton · Hamilton, Ontario · NCT04478305

• Creative arts program to help healthcare professionals with burnout

  This study is testing whether creative arts programs can help critical care healthcare professionals feel less burned out and improve their mental health.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04276922

• Online therapy for public safety personnel with mental health issues

  This study is testing an online therapy program to see if it can help Canadian public safety workers with depression, anxiety, or PTSD feel better and access mental health support more easily.

  Recruiting University of Regina · Regina, Saskatchewan · NCT04127032

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How genes affect depression, anxiety, and treatment response

  Researchers are using large, diverse genetic datasets from veterans and other groups to find gene patterns linked to depression, anxiety, and how people respond to treatments.

  NIH research Yale University · New Haven, United States · NIH-11325073

• Understanding how the immune system relates to mood symptoms in Alzheimer’s disease

  A doctor-scientist will study how immune system signals in people with Alzheimer’s relate to mood problems like depression, anxiety, and apathy to find new ways to help patients.

  NIH research University of Washington · Seattle, United States · NIH-11226377

• Understanding the genetics of depression and anxiety

  This study is looking at how our genes might influence major depression and anxiety disorders, using information from a large group of veterans, to help find better, more personalized treatments for these conditions.

  NIH research Yale University · New Haven, United States · NIH-11141904

Related topics

Quick answers

How many Depression, Anxiety clinical trials are recruiting right now?

37, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (20 trials), Canada (4 trials), China (3 trials), Italy (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 2, Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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