Understanding Androgen Excess and Metabolic Issues in Women with PCOS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on women diagnosed with polycystic ovary syndrome (PCOS), a condition that affects 10% of women and is associated with metabolic disorders. The researchers aim to identify measurable parameters that can predict the risk of future metabolic diseases in these women by collecting and analyzing phenome and metabolome data. Using machine learning techniques, the study will categorize PCOS patients into distinct subsets based on shared characteristics, which may help in understanding their metabolic risks. The findings could lead to better risk assessment and management strategies for women with PCOS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women with a suspected diagnosis of polycystic ovary syndrome
* Age range 18-70 years
* Ability to provide informed consent

Exclusion Criteria:

* Pregnancy or breastfeeding at the time of planned recruitment
* History of significant renal (eGFR\<30) or hepatic impairment (AST or ALT \>two-fold above ULN; pre-existing bilirubinaemia \>1.2 ULN)
* Any other significant disease or disorder that, in the opinion of the Investigator, may either put the participant at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
* Participants who have participated in another research study involving an investigational medicinal product in the 12 weeks preceding the planned recruitment
* Glucocorticoid use via any route within the last six months
* Current intake of drugs known to impact upon steroid or metabolic function or intake of such drugs during the six months preceding the planned recruitment
* Use of oral or transdermal hormonal contraception in the three months preceding the planned recruitment
* Use of contraceptive implants in the twelve months preceding the planned recruitment

Where it's running

• Wellcome Trust Clinical Research Facility
  Birmingham, West Midlands, United Kingdom Recruiting

Study contacts

• Principal investigator: Wiebke Arlt — University of Birmingham
• Study coordinator: Eka Melson
• Email: e.melson@bham.ac.uk
• Phone: +447852146611

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Precision acupuncture and lifestyle for PCOS

  This trial tests whether a precision acupuncture approach combined with a personalized lifestyle plan helps improve insulin resistance in people with PCOS compared with conventional acupuncture and standard lifestyle changes.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07809503

• Orlistat for metabolic and hormonal features in women with PCOS

  This trial tests whether adding orlistat to lifestyle advice helps improve metabolic and hormonal aspects in women with PCOS compared to lifestyle advice alone.

  Recruiting Khyber Medical University Peshawar · Abbottābād, Khyber Pakhtunkhwa · NCT07747909

• Physical activity program for women with PCOS and fatty pancreas plus subclinical hypothyroidism

  A program of exercise is being tested to see if it helps women with PCOS who also have fatty pancreas and subclinical hypothyroidism, compared to usual care.

  Recruiting Cairo University · Giza · NCT07591246

• Glucose monitoring in women with polycystic ovary syndrome

  This project will use continuous glucose monitors to see if daily glucose patterns differ among adult women with different PCOS phenotypes.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT07483723

• Adding regular exercise to a low‑calorie diet and metformin for women with PCOS and asthma

  This study will test whether adding regular treadmill walking to a low‑calorie diet and daily metformin helps women who have both PCOS and asthma.

  Recruiting Cairo University · Giza, Dokki · NCT07446985

• Identifying insulin-resistant PCOS with LMNA-related lipodystrophy in young women

  We’re testing whether women with a genetic insulin resistance and lipodystrophy differ from women with PCOS by age and BMI matching.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07412028

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.