The impact of androgens on liver health in women with Polycystic Ovary Syndrome.
Nonalcoholic Fatty Liver Disease (NAFLD) in Polycystic Ovary Syndrome: The Role of Androgens on Liver Injury and NAFLD Progression
This study is looking at how high levels of certain hormones in women with PCOS might harm their liver and lead to fatty liver disease, and it hopes to find ways to help improve liver health for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10914973 on NIH RePORTER |
What this research studies
This research investigates how elevated androgen levels in women with Polycystic Ovary Syndrome (PCOS) may contribute to liver injury and the progression of nonalcoholic fatty liver disease (NAFLD). The study aims to identify the mechanisms by which androgens affect liver health, particularly focusing on lipid metabolism and fat distribution. By understanding these relationships, the research seeks to explore potential therapeutic targets that could improve liver health in affected women. Participants may undergo assessments of hormone levels, liver function, and fat distribution to contribute to this important investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are reproductive-aged women diagnosed with Polycystic Ovary Syndrome who may also have elevated androgen levels and liver health concerns.
Not a fit: Patients without Polycystic Ovary Syndrome or those who do not have elevated androgen levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve liver health and reduce the risk of severe liver disease in women with PCOS.
How similar studies have performed: Previous research has indicated a link between androgens and liver disease in women, suggesting that this approach may yield valuable insights and potential breakthroughs.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Sarkar, Monika — University of California, San Francisco
- Study coordinator: Sarkar, Monika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.