How maternal genetics of polycystic ovary syndrome affects children's health outcomes
Official title: Effects of Maternal Genetic Risk Factors for Polycystic Ovary Syndrome on Birth and Childhood Outcomes in Offspring
Funded at Boston Children's Hospital · NIH-11119811 · Data updated 2026-11-12
This study is looking at how a mother's genes related to polycystic ovary syndrome (PCOS) might affect her child's health, especially regarding birth outcomes and conditions like obesity, to help find ways to support kids who may be at risk.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 9, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $178,000 |
| NIH project number | 1R03HD118217-01 |
| Project ID | NIH-11119811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include mothers diagnosed with polycystic ovary syndrome and their children, particularly those experiencing health issues related to metabolic and androgenic conditions.
✕Less likely to help
Patients who do not have a maternal history of polycystic ovary syndrome or related health conditions may not benefit from this research.
What this research studies
This research investigates the impact of maternal genetic factors associated with polycystic ovary syndrome (PCOS) on the health outcomes of their children. It aims to understand how these genetic factors may contribute to adverse birth outcomes and childhood conditions such as obesity and metabolic disorders. By analyzing data from mothers with PCOS and their offspring, the study seeks to differentiate between the effects of the intrauterine environment and inherited genetic traits. This could lead to targeted interventions to improve health outcomes for children at risk due to maternal PCOS.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing adverse health outcomes in children born to mothers with PCOS.
How similar studies have gone: Previous research has shown that maternal health conditions can significantly impact offspring health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Zhu, Jia — Boston Children's Hospital
- Study coordinator: Zhu, Jia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.