Condition

Coronary Heart Disease clinical trials and research

• 27Clinical trials
• 12NIH research projects
• 15Countries

Newest Coronary Heart Disease clinical trials

All recruiting trials (27)

• NMR-based Risk Test and Digital Health Support for midlife adults in Eloisa

  This study tests whether an NMR metabolomics risk test can guide tailored digital health programs for midlife adults at risk of diabetes, heart disease, stroke, kidney disease, or fatty liver.

  Recruiting University of Eastern Finland · Savonlinna · NCT07820800

• Prospective cardiac surgery cohort to improve perioperative care

  A multi-center study will test a large, forward-looking database of adults undergoing heart surgery to better understand what affects short- and long-term outcomes.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07662317

• Mazdutide and coronary plaque in people with coronary artery disease and overweight or obesity

  This study tests whether mazdutide can slow or reduce coronary plaque build-up in adults with coronary artery disease who are overweight or obese.

  Recruiting Phase 4 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07657676

• Understanding risk factors for cognitive problems in people with coronary heart disease

  In people with coronary heart disease, this study tests how metabolic factors and imaging features relate to cognitive impairment.

  Recruiting Beijing Anzhen Hospital · Beijing, China · NCT07657624

• Yiyang Huoluo Decoction for coronary heart disease with atherosclerosis in older adults

  This study will test whether adding the Yiyang Huoluo herbal decoction to standard heart care helps people aged 50–75 with coronary heart disease and atherosclerosis.

  Recruiting Phase 1/2 Hangzhou City University · Huzhou, Zhejiang · NCT07493603

• Glycocalyx and oxidative stress in blood vessel lining during coronary bypass surgery

  This project will see if changes in the endothelial glycocalyx and oxidative stress markers relate to microvascular function and outcomes in adults having elective coronary artery bypass grafting.

  Recruiting Josip Juraj Strossmayer University of Osijek · Osijek · NCT07451873

• One-month vessel healing after BioFreedom polymer-free drug-coated stent versus Xience drug-eluting stent in heart attack patients with high bleeding risk

  We'll use very detailed optical imaging to see if the polymer-free BioFreedom stent leads to faster or better vessel healing than the Xience stent in people with a recent heart attack who are at high bleeding risk.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07230847

• CTCA before invasive angiography in people with prior CABG

  This study tests whether a CTCA-guided plan before invasive angiography can reduce major heart-related events in people who had CABG and now have chest pain or a heart attack.

  Recruiting Queen Mary University of London · London · NCT07165678

• Sivelestat sodium treatment after off-pump coronary artery bypass grafting (OPCABG)

  This trial will test whether giving sivelestat sodium after off-pump coronary bypass surgery helps protect the heart and reduce inflammation in adults having OPCABG.

  Recruiting Phase 2 Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07118930

• Yangxinshi tablets for people with coronary heart disease and heart dysfunction

  This trial tests whether adding Yangxinshi tablets to usual care helps people aged 40–80 with coronary heart disease and cardiac dysfunction have fewer heart-related events and better exercise tolerance and quality of life.

  Recruiting Phase 4 SPH Qingdao Growful Pharmacetical Co.,Ltd · Haozhou, Anhui and 95 other locations · NCT07110415

• Innovative approaches for personalized cardiovascular prevention

  This study is testing if using genetic information and smartwatches can help people make healthier choices to prevent heart disease.

  Recruiting at 7 sites Catholic University of the Sacred Heart · Rome, Italy and 6 other locations · NCT06911294

• Cognitive Behavioral Therapy for Insomnia in Heart Disease Patients

  This study tests whether Cognitive Behavioral Therapy for Insomnia can help people with heart disease sleep better and improve their heart health.

  Recruiting Vestre Viken Hospital Trust · Drammen, Buskerud · NCT06749951

• Individualized exercise program for elderly patients with coronary heart disease

  This study tests whether a personalized exercise program can help older patients with coronary heart disease feel better physically and mentally.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06588231

• Exercise training for women with heart disease

  This project will test whether virtual high-intensity interval training (HIIT) or virtual moderate-to-vigorous continuous training (MICT) better improves fitness, mental health, and quality of life in women with coronary heart disease.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06494163

• Xuesaitong soft capsules to lower inflammation and improve risk markers in people with coronary heart disease

  This trial tests whether Xuesaitong soft capsules lower hsCRP and improve other cardiovascular risk markers in adults with stable coronary heart disease who are already on statins and antiplatelet therapy.

  Recruiting Phase 4 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality and 1 other locations · NCT06425120

• Assessing cardiovascular and kidney health using metabolomics in patients with heart disease

  This study is testing if certain fat-related substances in the blood can help predict health outcomes for adults with both heart disease and kidney problems.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT06383208

• Thiamine treatment for cognitive issues after heart surgery

  This study is testing if giving thiamine to patients with heart disease after heart surgery can help improve their thinking and memory skills.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT06326996

• Lifestyle medicine program to help rural adults with multiple chronic conditions

  This program will try supervised exercise and lifestyle coaching for rural adults aged 18–64 who have two or more chronic conditions to see if access to a wellness facility improves their health.

  Recruiting West Virginia School of Osteopathic Medicine · Lewisburg, West Virginia · NCT06049420

• Evaluating biomarkers for coronary heart disease prognosis

  This study is trying to find out which blood and stool markers can help predict health outcomes for people with coronary heart disease over two years.

  Recruiting Shandong First Medical University · Jinan, Shandong · NCT05699629

• Research on heart and kidney disease interactions

  This study looks at how heart and kidney problems affect each other to find better treatment options for people with cardiorenal syndrome.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing · NCT05397392

• Exploring the link between unstable angina and anxiety-depressive syndrome

  This study looks at how unstable angina and anxiety or depression are connected in people with heart disease by checking their blood for certain markers.

  Recruiting Samarkand State Medical Institute · Samarkand · NCT04599621

• Personalized prevention program for patients with high-risk stable coronary heart disease

  This study is testing a personalized prevention program to see if it can help people with high-risk stable coronary heart disease avoid heart problems better than regular care.

  Recruiting at 3 sites Tampere University · Helsinki and 25 other locations · NCT04433052

• Research on health inequality and genetic disparity in cardiovascular diseases

  This study is trying to understand how health differences and genetics affect heart diseases in people from various ethnic backgrounds in the UK to help improve treatments for everyone.

  Recruiting Future Genetics Limited · Wolverhampton, West Midlands · NCT03987633

• Assessing the impact of comorbidities on postoperative complications.

  This study looks at how having other health issues affects the chances of complications after abdominal surgery to help doctors better understand and manage risks for their patients.

  Recruiting at 37 sites Russian Federation of Anesthesiologists and Reanimatologists · Arkhangelsk and 37 other locations · NCT03945968

• A large health study in Hamburg focusing on chronic diseases

  This study is trying to find out what causes chronic diseases by looking at the health and lifestyle of 45,000 people aged 45 to 74 in Hamburg, Germany, and checking in with them over time.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT03934957

• Evaluating frailty in elderly patients undergoing heart procedures

  This study looks at how frailty affects the recovery and outcomes of heart procedures in older patients aged 65 and up with coronary artery disease.

  Recruiting Medical University of Silesia · Zabrze, Upper Silesia · NCT03209414

• Registry of emotional stress in patients undergoing coronary interventions

  This study looks at how emotional stress affects the long-term health of people with heart disease after they have heart procedures.

  Recruiting Tilburg University · Tilburg, North Brabant · NCT02621216

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Pay-what-you-can cafes and heart health in people with high blood pressure and food insecurity

  This project tests whether eating at pay-what-you-can cafes improves blood pressure and heart- disease related outcomes for hypertensive adults who face food insecurity.

  NIH research Texas A&m Agrilife Research · College Station, UNITED STATES · NIH-11448249

• Apolipoprotein Proteoforms and Heart Health

  This grant aims to understand how different chemical changes to apolipoproteins relate to cholesterol, obesity, insulin resistance, and risk of heart disease in people.

  NIH research Northwestern University · Chicago, United States · NIH-11417166

• Metal exposures and heart disease: how genes and mixtures shape risk

  A large study from NYU aims to understand how exposure to arsenic and other metals, together with genetic factors, influence the risk of coronary heart disease in diverse adults.

  NIH research New York University School of Medicine · New York, United States · NIH-11372279

• How stress-linked gene changes may raise heart disease risk

  This project looks at whether stress-related chemical changes on DNA in blood immune cells help explain higher heart disease risk in people exposed to chronic psychosocial stress.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11326344

• Genetic clues to blood fats and heart disease progression

  Researchers are studying how genetic differences affect blood lipid levels and heart disease risk so doctors can tailor prevention for people at different ages.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11293111

• PFAS chemicals, blood lipoproteins, and coronary heart disease risk

  Researchers will look at whether common environmental chemicals called PFAS are linked to specific blood lipoproteins and higher risk of coronary heart disease in adults.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11285433

• Metals and Heart Disease in Different Communities

  This project looks at how exposure to different metals might affect heart health in various groups of people.

  NIH research New York University School of Medicine · New York, United States · NIH-11196717

• Investigating how environmental pollutants affect heart disease risk

  This study is looking at how certain chemicals found in the environment might affect heart health, specifically how they could influence cholesterol levels and increase the risk of heart disease, and it invites people to share their health information and blood samples to help with this important research.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11075864

• How stress affects heart disease through genetic changes

  This study is looking at how stress affects heart health by checking changes in our DNA that might happen because of stress, and it's for anyone interested in understanding how stress could lead to heart problems.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11052522

• How exposure to mixtures of toxic metals affects heart disease risk

  This study is looking at how being around certain toxic metals, like arsenic, might affect your heart health, especially for people who may be more at risk for heart disease, and it aims to find out if being exposed to a mix of these metals is different from just being exposed to one at a time.

  NIH research New York University School of Medicine · New York, United States · NIH-10821725

• Using advanced models to predict stroke and heart disease risk

  This study is working on creating personalized tools to help predict the risk of stroke and heart disease for people, so that those at higher risk can get more targeted care while others can be managed with less intensive treatments.

  NIH research New York University · New York, United States · NIH-10678650

• Investigating how gut microbes affect heart disease risk

  This study is looking at how certain substances made by gut bacteria from the food we eat might affect the risk of heart disease, and it aims to find new ways to help prevent it for people from different backgrounds and diets.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10654667

Related topics

Quick answers

How many Coronary Heart Disease clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in China (12 trials), United States (2 trials), Finland (2 trials), Germany (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Early Phase 1: 1, Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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