Investigating early signs of Polycystic Ovary Syndrome in young girls
Developmental Origins of Polycystic Ovary Syndrome: Very Early Phenotypes During the Mini Puberty of Infancy and Beyond
This study is looking at how Polycystic Ovary Syndrome (PCOS) might start in young girls, especially those whose moms have it, by checking hormone changes during a special time in infancy called 'mini puberty' to find early signs that could show if they might develop PCOS later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10815753 on NIH RePORTER |
What this research studies
This research focuses on understanding how Polycystic Ovary Syndrome (PCOS) develops in young girls, particularly those who have mothers with the condition. It examines the hormonal changes that occur during a critical developmental phase known as 'mini puberty' in infancy, which may reveal early reproductive traits linked to PCOS. By studying these early phenotypes, the research aims to identify potential markers that could indicate a higher risk of developing PCOS later in life. The approach includes careful monitoring of hormone levels and other biological indicators in infants at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are young girls, particularly those under the age of two, who have mothers diagnosed with Polycystic Ovary Syndrome.
Not a fit: Patients who do not have a family history of PCOS or are older than two years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification and intervention strategies for girls at risk of developing PCOS, potentially improving their long-term reproductive and metabolic health.
How similar studies have performed: While research on PCOS is extensive, this specific focus on early developmental phenotypes during infancy is relatively novel and has not been extensively tested.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Torchen, Laura C — Lurie Children's Hospital of Chicago
- Study coordinator: Torchen, Laura C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.