Identifying Women at Risk for Placental Dysfunction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of the Fetal Medicine Foundation's pre-eclampsia risk calculator by analyzing maternal characteristics, first trimester serum placental growth factor (PlGF), and mean arterial pressure (MAP) in a Finnish population. A total of 3000 pregnant women will be recruited during their first maternity care visit, with blood samples collected in the first and third trimesters. Participants will be categorized into risk, control, and polycystic ovary syndrome (PCOS) groups based on pre-eclampsia risk calculations. Additionally, ultrasound scans will be performed for certain groups at 30-32 weeks of gestation to monitor pregnancy outcomes.

Why it matters

Who can join: the full rules

Mothers

Inclusion Criteria for PEPPI-study

* Pregnant (first trimester)
* Understands Finnish
* ≥18 years
* Signed informed consent

Exclusion Criteria

* Multiple pregnancy
* Miscarriage/termination of the index pregnancy
* No first trimester blood sampling

Inclusion Criteria for FERPPI-study

* Participates in PEPPI-study (criteria above)
* Blood samples at first and third trimester of pregnancy
* Permits blood sampling from the umbilical cord when the baby is born

Exclusion Criteria

* No first or third trimester blood sampling
* No umbilical cord blood sample after baby is born

Fathers

Inclusion Criteria

* Biological father to the child born for the mother who participated in PEPPI study
* ≥18 years
* Signed informed consent

Exclusion Criteria

• Does not understand Finnish

Children

Inclusion Criteria for PEPPI-study

* Born to mother who participated in PEPPI study
* Signed informed consent from parent(s)

Exclusion Criteria

• No consent from parent(s)

Inclusion Criteria for PEPPI-offspring study • Mother in risk-, control-, or PCOS group during PEPPI-study with ultrasound information at gestational weeks 30-32 or a mother who developed pre-eclampsia during the pregnancy regardless of their study group during PEPPI-study

Exclusion Criteria

• Mother/father declines participation

Inclusion Criteria for FERPPI-study

* Signed informed consent from parent(s)
* Mother has blood samples taken at first and third trimester (iron status)
* Child has blood samples taken at birth and at 3 months of age

Exclusion Criteria

* No consent from parent(s)
* No blood samples from mother
* No blood samples from child

Where it's running

• The Wellbeing Services County of North Ostrobothnia
  Oulu, Finland Recruiting

Study contacts

• Principal investigator: Jaana Nevalainen, Assoc prof — The Wellbeing Services County of North Ostrobothnia
• Study coordinator: Jaana E Nevalainen, Assoc prof
• Email: jaana.nevalainen@oulu.fi
• Phone: +358405801857

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pre-eclampsia risk in pregnancies after oocyte donation

  We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.

  Recruiting at 6 sites Copenhagen University Hospital, Hvidovre · Copenhagen and 5 other locations · NCT07263490

• Use of metformin to prolong pregnancy in preterm preeclampsia in the Netherlands

  In pregnant people with preterm preeclampsia, this study tests whether metformin can help them stay pregnant longer compared with placebo.

  Recruiting Phase 3 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06452498

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• Intravenous iron infusion after transcatheter aortic valve implantation for people with iron deficiency

  This trial will test whether an intravenous iron infusion after TAVI helps people aged 65 and older with severe aortic stenosis and iron deficiency feel better and walk farther.

  Recruiting Phase 4 Erasmus Medical Center · Rotterdam, South Holland · NCT07370688

• Cardiac and fetal health in pregnancy at high altitude

  This observational study tests how living at high altitude affects heart function and fetal growth in pregnant women, compared with similar pregnancies at sea level.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07312227

• Investigating cardiovascular risks in women after complicated pregnancies

  This study looks at how having high blood pressure during pregnancy might affect women's heart health later on and whether certain blood tests can help predict their risk for heart problems.

  Recruiting Maastricht University Medical Center · Maastricht · NCT05500989

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.