Investigating how semaglutide can help restore ovulation in people with polycystic ovary syndrome.
Official title: Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome
Funded at University of Colorado Denver · NIH-10904665 · Data updated 2026-11-12
This study is looking at how the medication semaglutide can help people with polycystic ovary syndrome (PCOS) by restoring their ovulation and improving their hormone balance, especially for those who are overweight or obese.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $528,380 |
| NIH project number | 5R01HD108340-02 |
| Project ID | NIH-10904665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents and adults diagnosed with polycystic ovary syndrome, particularly those who are overweight or obese.
✕Less likely to help
Patients without polycystic ovary syndrome or those who are not overweight may not benefit from this research.
What this research studies
This research focuses on the effects of semaglutide, a medication typically used for diabetes and weight management, on restoring ovulation in individuals with polycystic ovary syndrome (PCOS). The study aims to evaluate how this treatment can improve insulin sensitivity and hormonal balance, which are often disrupted in PCOS. Participants will receive semaglutide and be monitored for changes in menstrual cycles, hormone levels, and overall reproductive health. The research seeks to provide a new therapeutic option for managing PCOS symptoms, particularly in those who are overweight or obese.
Why it matters
Potential benefit: If successful, this research could offer a new treatment option for individuals with PCOS, potentially restoring ovulation and improving reproductive health.
How similar studies have gone: Previous studies with other GLP-1 receptor agonists have shown promising results in improving menstrual frequency and hormonal levels in women with PCOS, suggesting potential success for this approach.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Cree, Melanie G — University of Colorado Denver
- Study coordinator: Cree, Melanie G
Related research
Other NIH-funded projects on the same topics.
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SMAD5 and PCOS/PMOS: a new genetic clue to infertility
A research project at Baylor College of Medicine is studying a genetic variant in SMAD5 that may cause a form of PCOS/PMOS and could lead to new ways to diagnose or treat infertility.
-
TLR4 blocker for improving fertility in PCOS
A promising, already-approved drug (disulfiram) will be tested to see if it can reduce inflammation and improve ovulation in women with PCOS.
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Genetic clues to PCOS: how genes shape a common women's health condition
A doctor-scientist team at Boston Children’s Hospital is studying how genetic factors contribute to polycystic ovary syndrome (PCOS) across women, men, and children to understand the root causes.
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Semaglutide to help restore ovulation in youth and adults with PCOS
A study tests an oral GLP-1 receptor agonist (semaglutide) to improve ovulation and hormonal balance in people with polycystic ovary syndrome (PCOS).
-
Understanding how PCOS develops during adolescence
This grant looks at how polycystic ovary syndrome begins in teenagers and what early signs help doctors diagnose it accurately.
-
AI-powered ultrasound tool to help diagnose PCOS
A new AI-based tool uses ultrasound images to help doctors reliably identify polycystic ovary syndrome (PCOS) in reproductive-age women.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.