Investigating how semaglutide can help restore ovulation in people with polycystic ovary syndrome.
Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome
This study is looking at how the medication semaglutide can help people with polycystic ovary syndrome (PCOS) by restoring their ovulation and improving their hormone balance, especially for those who are overweight or obese.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10904665 on NIH RePORTER |
What this research studies
This research focuses on the effects of semaglutide, a medication typically used for diabetes and weight management, on restoring ovulation in individuals with polycystic ovary syndrome (PCOS). The study aims to evaluate how this treatment can improve insulin sensitivity and hormonal balance, which are often disrupted in PCOS. Participants will receive semaglutide and be monitored for changes in menstrual cycles, hormone levels, and overall reproductive health. The research seeks to provide a new therapeutic option for managing PCOS symptoms, particularly in those who are overweight or obese.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and adults diagnosed with polycystic ovary syndrome, particularly those who are overweight or obese.
Not a fit: Patients without polycystic ovary syndrome or those who are not overweight may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a new treatment option for individuals with PCOS, potentially restoring ovulation and improving reproductive health.
How similar studies have performed: Previous studies with other GLP-1 receptor agonists have shown promising results in improving menstrual frequency and hormonal levels in women with PCOS, suggesting potential success for this approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Cree, Melanie G — University of Colorado Denver
- Study coordinator: Cree, Melanie G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.