Understanding SMAD5 Signaling in Polycystic Ovary Syndrome
SMAD5 signaling in Polycystic Ovary Syndrome
This project looks at how a specific signal, SMAD5, might be involved in Polycystic Ovary Syndrome (PCOS) to better understand its link to overall health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11143252 on NIH RePORTER |
What this research studies
Polycystic Ovary Syndrome (PCOS) can affect both a woman's reproductive health and her overall well-being, increasing risks for conditions like infertility, obesity, and diabetes. While excess hormones like androgens are known to play a role, we don't fully understand how ovarian issues connect to other health problems in PCOS. This project explores a newly found genetic variation in a protein called SMAD5, identified in a mother and daughter with PCOS. By studying this specific genetic change, we hope to uncover new insights into the complex causes of PCOS.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the biology of Polycystic Ovary Syndrome using existing clinical and genomic data.
Not a fit: Patients not diagnosed with Polycystic Ovary Syndrome would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of PCOS, potentially paving the way for new ways to prevent or treat its various health complications.
How similar studies have performed: This exploratory project builds upon clinical and genomic data from specific PCOS patients, aiming to fill a knowledge gap in the cause-and-effect relationship of PCOS phenotypes.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Pangas, Stephanie a. — Baylor College of Medicine
- Study coordinator: Pangas, Stephanie a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.