Investigating the role of SMAD5 signaling in Polycystic Ovary Syndrome
SMAD5 signaling in Polycystic Ovary Syndrome
This study is looking at how reproductive health and overall well-being are connected in women with Polycystic Ovary Syndrome (PCOS), focusing on how certain hormones affect both reproductive and other health issues, and it invites women with PCOS to help by sharing health information and samples.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10975693 on NIH RePORTER |
What this research studies
This research explores the connection between reproductive health and overall well-being in women with Polycystic Ovary Syndrome (PCOS). It focuses on understanding how hormonal changes, particularly involving anti-Mullerian hormone (AMH) and androgens, contribute to both reproductive and non-reproductive health issues associated with PCOS. By analyzing clinical and genomic data from affected families, the study aims to uncover the underlying mechanisms of PCOS and its related health risks. Patients may be involved in providing biological samples and health information to support this investigation.
Who could benefit from this research
Good fit: Ideal candidates for participation include women diagnosed with Polycystic Ovary Syndrome, particularly those with a family history of the condition.
Not a fit: Patients without a diagnosis of Polycystic Ovary Syndrome or those who do not have a family history of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women suffering from PCOS and its associated health complications.
How similar studies have performed: Previous research has shown promising results in understanding hormonal influences in PCOS, but this specific approach using SMAD signaling is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Pangas, Stephanie a. — Baylor College of Medicine
- Study coordinator: Pangas, Stephanie a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.