Condition

Dry Eye clinical trials and research

• 34Clinical trials
• 25NIH research projects
• 9Countries

Newest Dry Eye clinical trials

All recruiting trials (34)

• Lacrifill to Help Prevent Post-Curgery Dry Eye After Cataract Surgery

  This study tests Lacrifill to see if it helps prevent dry eye symptoms after unilateral cataract surgery.

  Recruiting at 2 sites Phase 4 Eye Research Associates, LLC · Pittsburg, Kansas and 1 other locations · NCT07796178

• Tear-Fluid Stability Testing with iTrace, BOSA, OPD-Scan III, and IDRA for Dry Eye

  A Phase 4 study tests whether four eye devices can detect tear film stability in adults with normal tear film.

  Recruiting Phase 4 Vance Thompson Vision · Sioux Falls, South Dakota · NCT07790211

• OT202 1% eye drops for moderate to severe dry eye

  This phase 3 study tests whether 1% OT202 eye drops help people with moderate to severe dry eye better than a placebo.

  Recruiting Phase 3 Ocumension Therapeutics (Suzhou) Co., Ltd · Bengbu, Anhui and 48 other locations · NCT07740564

• Tyrvaya Nasal Spray for Comfort in Contact Lens Wearers

  This study tests whether using Tyrvaya twice daily can improve comfort for adults who wear soft contact lenses and have dry eye symptoms.

  Recruiting Ocular Aesthetics, LLC dba Ocular Clinical Trials · Houston, Texas · NCT07705893

• Long-term effects of Acoltremon vs. control in dry eye disease

  This study tests whether Acoltremon eye drops help people with dry eye over a year compared with a preservative-free artificial tear, at a single center.

  Recruiting The Eye Care Institute · Louisville, Kentucky · NCT07659626

• Effect of Dry Eye Treatment on Corneal Astigmatism Measurements

  This study tests whether short-term treatment for dry eye changes how consistently three devices measure corneal astigmatism in people preparing for cataract surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07657858

• Autologous Serum Eye Drops for Severe Dry Eye: Protein Factors and Response

  This study tests whether the protein makeup of a patient’s own serum eye drops explains how well those drops work for severe dry eye.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT07632534

• See if rinsing the eye reduces inflammation and symptoms in severe dry eye

  This trial tests whether rinsing the surface of the eye can lower inflammation and improve symptoms for people with severe dry eye disease.

  Recruiting Rinsada · Pittsburgh, Pennsylvania · NCT07618364

• Nasal spray eye treatment to help dry eye with meibomian gland dysfunction

  This study tests whether a nasal spray containing varenicline can improve tear film and eye surface in adults with uncomfortable dry eye caused mainly by meibomian gland dysfunction.

  Recruiting Phase 4 University of California, Berkeley · Berkeley, California · NCT07606625

• Artelac Complete MDO vs VISMED Multi eye drops for moderate to severe dry eye disease

  This trial tests whether Artelac Complete MDO eye drops work as well as VISMED Multi eye drops for people with moderate to severe dry eye disease.

  Recruiting at 9 sites Bausch & Lomb Incorporated · Freiburg im Breisgau, Baden-Wurttemberg and 11 other locations · NCT07593885

• Comparing devices that measure the eye's lipid layer thickness

  This test compares three common devices to see which gives the most consistent lipid layer thickness measurements in people with dry eye.

  Recruiting Indiana University · Bloomington, Indiana · NCT07579130

• VEVYE (cyclosporine 0.1%) for short-term symptom and sign improvement in dry eye at a neuro-ophthalmology clinic

  This project will test whether VEVYE (cyclosporine 0.1% eye drops) improves symptoms and clinical signs in adults with dry eye disease seen in a neuro-ophthalmology clinic, including some people with neurotrophic keratitis.

  Recruiting Neuro-Ophthalmology of Texas · Houston, Texas · NCT07566975

• Detecting severe dry eye and improving its treatment

  We will test whether an AI tool that analyzes one corneal photo can better find adults with severe dry eye who need specialist treatment, compared with or added to a short DEQ-5 questionnaire.

  Recruiting Singapore National Eye Centre · Singapore · NCT07554911

• Lacrifill for contact lens wearers with dry eye who can't wear lenses comfortably

  This trial will try Lacrifill eye drops in adults with dry eye who have trouble wearing contact lenses to see if regular use helps them wear lenses longer with less discomfort.

  Recruiting Phase 4 Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists · Kingston, Pennsylvania · NCT07510620

• Autologous Serum Tears with Hyaluronate vs Standard Serum Tears for Moderate-to-Severe Dry Eye

  This study tests whether adding sodium hyaluronate to autologous serum eye drops provides better relief for adults with moderate-to-severe dry eye in one eye, compared with the standard serum drops in the other eye.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT07413172

• Exercise and diet to reduce eye dryness in women with PCOS and obesity

  We will test whether adding regular treadmill walking to metformin and a low-calorie diet helps reduce eye dryness in obese women with PCOS.

  Recruiting Cairo University · Giza, Dokki · NCT07366944

• Tear protein changes before and after low-level light therapy for dry eye and meibomian gland dysfunction

  This research will test whether low-level light therapy changes proteins in tears and helps people with dry eye and meibomian gland problems.

  Recruiting Singapore National Eye Centre · Singapore · NCT07329712

• Ocular surface diagnostics and care plans to improve cataract surgery results

  This project will try using new tear and cornea imaging plus tailored preoperative care to help people with dry eye get better vision after cataract surgery.

  Recruiting Singapore National Eye Centre · Singapore · NCT07323264

• Three-minute eyelid closure to improve corneal curvature readings

  This tests whether gently closing the eyelid for three minutes before corneal measurements helps improve keratometry accuracy for adults with a 'warning' keratometry quality index who are planning cataract surgery.

  Recruiting Vienna Institute for Research in Ocular Surgery · Vienna, State of Vienna · NCT07297849

• How TRYPTYR affects quality of life and the ability to work for people with dry eye

  This one-month test will see if TRYPTYR (acoltremon) eye drops help adults with chronic dry eye produce more tears, reduce symptoms, and improve their ability to do work.

  Recruiting at 3 sites Phase 4 Southern College of Optometry · Pittsburg, Kansas and 2 other locations · NCT07266948

• JN002 eye drops for dry eye disease

  This trial will test whether JN002 eye drops, given three times daily at two different doses, help adults with dry eye disease feel better and improve eye test results compared with placebo.

  Recruiting Early Phase 1 Eye & ENT Hospital of Fudan University · Shanghai · NCT07245017

• Stem cell–fortified eye drops to improve tear stability and dry eye symptoms in people with cataract or dry eye

  This will test stem cell‑fortified eye drops to improve tear film stability, increase tear volume, and ease dry eye symptoms in adults with dry eye disease, including those with cataract.

  Recruiting Phase 4 Ace Cells Lab Limited · Giza · NCT07191847

• Eight-week test of VSJ-110 versus placebo for dry eye

  This eight-week test will see if VSJ-110 reduces dry eye symptoms better than a placebo in adults with dry eye.

  Recruiting at 2 sites Phase 2 Vanda Pharmaceuticals · Newport Beach, California and 4 other locations · NCT07179055

• Low-level red light therapy and eyelid temperature across different skin tones

  This will see if low-level red light therapy changes eyelid temperature in adults with dry eye and meibomian gland dysfunction who have lighter versus darker skin.

  Recruiting University of Houston · Houston, Texas · NCT07173530

• Kera Sol eye drops for temporary dry eye after LASIK

  This study will test whether using Kera Sol eye drops four times a day for two weeks helps adults who experience temporary dry eye after LASIK.

  Recruiting Phase 4 Vance Thompson Vision · Sioux Falls, South Dakota · NCT07155070

• Qlosi eye drops to improve daily life for people with presbyopia

  This trial will test whether Qlosi 0.4% eye drops, used twice daily, can improve quality of life for people aged 45–64 who have presbyopia and need near vision help.

  Recruiting at 2 sites Phase 4 Southern College of Optometry · Medina, Minnesota and 1 other locations · NCT07113210

• Using Acthar Gel to treat moderate-severe keratitis in autoimmune patients

  This study is testing if Acthar Gel can help people with autoimmune diseases and dry eye feel less eye pain and improve their eye health over 12 weeks.

  Recruiting Phase 4 Toyos Clinic · Nashville, Tennessee · NCT06964269

• Combining exercise with intermittent fasting to improve eye dryness in pre-diabetic psoriasis patients

  This study is testing if combining exercise with intermittent fasting can help reduce eye dryness in people with psoriasis and prediabetes.

  Recruiting Cairo University · Giza, Dokki · NCT06893913

• Investigating the role of corneal nerves in dry eye disease

  This study looks at how the nerves in the eye relate to dry eye symptoms to see if they can help explain why some people have worse dry eye than others.

  Recruiting University of Applied Sciences and Arts Northwestern Switzerland · Olten · NCT06841471

• Using cord blood eye drops to heal corneal damage in lung cancer patients

  This study is testing if eye drops made from cord blood can help lung cancer patients with EGFR mutations heal their eye damage caused by treatment.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06830551

• Evaluating a new eye drop for dry eye disease

  This study is testing a new eye drop for dry eye disease to see if it can help people aged 30 to 80 feel better and improve their eye health.

  Recruiting Phase 3 VivaVision Biotech, Inc · Shanghai, Shanghai Municipality · NCT06360133

• How eyeliner affects tear composition, tear secretion, and tear film stability

  This test checks whether wearing eyeliner changes tear composition, tear secretion, and tear film stability in adults aged 20–35 who either regularly use eyeliner or do not use it.

  Recruiting Zhongnan Hospital · Wuhan, Hubei · NCT05632887

• Observational study on dry eye in patients with primary Sjögren's syndrome

  This study looks at people with primary Sjögren's syndrome who have severe dry eye symptoms to see how their condition affects their eyes and what can be learned from their tear and blood samples.

  Recruiting Peking University Third Hospital · Beijing · NCT05605314

• Advanced imaging techniques for eye conditions

  This study is testing new advanced imaging techniques to see if they can help doctors better understand and diagnose eye diseases like retinitis pigmentosa and maculopathy.

  Recruiting Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts · Paris · NCT04129021

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Stabilizing the tear film to relieve evaporative dry eye

  This project tests new ways to stabilize the tear film in people with evaporative dry eye, with the goal of longer-lasting comfort.

  NIH research Michigan State University · East Lansing, United States · NIH-11641969

• Understanding migraine and eye pain: how light and nerves cause discomfort in migraine and dry eye

  A research project is studying why eye pain and sensitivity to light happen in people with migraine and dry eye, and how surgery to correct vision may contribute to these symptoms.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11418908

• A new way to understand evaporative dry eye

  Researchers are building a lab model to better understand why people develop evaporative dry eye so treatments can be improved.

  NIH research Michigan State University · East Lansing, United States · NIH-11398342

• Mitigating Dry Eye Symptoms by Improving Indoor Air Quality

  Aimed at adults with dry eye symptoms, this study tests a low-cost, multi-faceted plan to improve indoor air and reduce eye discomfort.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11344220

• Understanding tear film thickness to help diagnose and manage dry eye

  A study at a U.S. university will look at how the thin outer layer of tears changes in people with dry eye and how those changes relate to their symptoms and clinical signs.

  NIH research University of South Florida · Tampa, United States · NIH-11319894

• Tear microRNA patterns in women and men with dry eye

  Researchers will look at tiny RNA molecules in tear fluid from people with dry eye to find patterns linked to sex and race.

  NIH research Augusta University · Augusta, United States · NIH-11311871

• Immune causes of chronic dry eye

  This work looks at how certain immune cells make dry eye persist in adults and aims to point toward better, longer-lasting treatments.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11237037

• A new type of plug to help relieve dry eye symptoms

  This study is working on a new type of eye plug that can help make life easier for people with dry eyes by using special materials that adjust to their needs, aiming to provide more comfort and better results than current treatments.

  NIH research Aesculatech, INC. · Los Angeles, UNITED STATES · NIH-11216481

• Why migraine and dry eye cause eye pain and light sensitivity

  This project looks for nerve and immune changes that make people with migraine, dry eye, or after refractive eye surgery feel eye pain and sensitivity to light.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11170416

• Preventing dry eye disease and age-related Meibomian gland dysfunction

  This study is looking at how changing the support structure around eye glands might help prevent dry eye and related issues as we age, and it aims to find new ways to help people who struggle with dry eyes.

  NIH research University of Houston · Houston, United States · NIH-11160450

• Why dry eye gets worse in autoimmune disease

  Researchers are mapping the different cell types in the cornea and how they change in people with autoimmune-related dry eye to help find ways to protect the eye and relieve symptoms.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11138650

• Investigating the relationship between tear film thickness and dry eye symptoms

  This study is looking at how the thickness of a special layer in your tears might be connected to dry eye symptoms, with the goal of finding better ways to spot dry eye early on, even before you feel any discomfort.

  NIH research University of South Florida · Tampa, United States · NIH-11132864

• Investigating tear fluid differences in dry eye disease based on sex and race

  This study is looking at dry eye disease to find out how certain tiny molecules in your tears can help us understand the condition better and create personalized treatments, especially for women and specific racial groups who may be more affected.

  NIH research Augusta University · Augusta, United States · NIH-11117178

• Developing a new treatment for dry eye disease caused by Sjogren's syndrome

  This study is testing a new, easy-to-get treatment for dry eyes caused by Sjogren's syndrome, using special cells to create a healing extract that could help improve your symptoms and overall eye health.

  NIH research Stellular Bio, INC. · Watertown, United States · NIH-11067525

• Understanding how dry eye disease progresses

  This study is looking into how dry eye disease gets worse in people with autoimmune conditions like Sjögren's syndrome and rheumatoid arthritis, to help find better ways to manage the symptoms by understanding the changes happening in the eye.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11046163

• Understanding evaporative dry eye disease and its causes

  This study is looking at dry eye disease by using special mice that have a gene missing, which helps researchers learn more about what causes this common eye problem and how we might be able to treat it better in people.

  NIH research University of California at Davis · Davis, United States · NIH-11039647

• Understanding the tear film lipid layer to improve dry eye treatment

  This study is looking at the oily layer in your tears that helps keep your eyes moist, and it's especially for people with chronic dry eye, as it aims to understand why this layer sometimes doesn't work well and how we might improve treatments for you.

  NIH research University of Louisville · Louisville, United States · NIH-11000857

• Understanding tear film stability to create new treatments for dry eye disease

  This study is looking at how to make tears last longer for people with dry eye by exploring a special ingredient found in rabbit tears that could help improve tear stability, with the hope of creating a new treatment that brings better relief for those suffering from evaporative dry eye disease.

  NIH research University of California at Davis · Davis, United States · NIH-10983731

• Exploring how social factors affect access to eye care for dry eye disease

  This study looks at how factors like race, ethnicity, and language affect people's access to eye care and their experiences with dry eye disease, aiming to find ways to improve treatment and support for patients over the next two years.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10950592

• Improving treatment for dry eye disease using nerve growth factor

  This study is testing a new eye treatment that uses a special form of nerve growth factor to help people over 50 who have dry eye disease, aiming to improve their symptoms and tear production for better vision and comfort.

  NIH research Human Cell Co · Naperville, United States · NIH-10916847

• Understanding pain and light sensitivity in migraine and dry eye conditions

  This study is looking into why people with migraines and dry eye often feel pain and sensitivity to light, hoping to find new ways to help treat these uncomfortable symptoms.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10913444

• Understanding how dry eye disease progresses

  This study is looking into how dry eye disease, especially when connected to autoimmune issues like Sjögren's syndrome and rheumatoid arthritis, affects the cells in your eyes, with the hope of finding new ways to help manage the condition.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10898842

• Understanding how aging affects dry eye disease through specific proteins

  This study is looking at how aging affects dry eye symptoms and how a protein called cathepsin S might play a role in causing inflammation in the eyes of older adults, with the goal of finding better treatments for dry eye disease.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10703450

• Investigating how Cathepsin S affects pain in dry eye conditions

  This study is looking at how a specific protein called Cathepsin S affects nerve pain related to dry eye syndrome, especially in older adults who often feel a lot of discomfort even when their eyes don’t look too bad, with hopes of finding new ways to help relieve that pain.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10671531

• Investigating the role of the immune system in dry eye disease linked to Sjögren's syndrome

  This study is looking at how the immune system affects dry eye disease in people with Primary Sjögren's syndrome, with the goal of finding new ways to identify and treat this condition to help improve eye health and comfort.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10561638

Related topics

Quick answers

How many Dry Eye clinical trials are recruiting right now?

34, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (16 trials), China (6 trials), Singapore (3 trials), Egypt (3 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 9, Phase 2: 2, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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