Condition

Lung Transplant clinical trials and research

• 23Clinical trials
• 49NIH research projects
• 1New in 30 days
• 7Countries

Newest Lung Transplant clinical trials

All recruiting trials (23)

• Multidisciplinary non-drug program to improve quality of life after solid organ transplant

  A multidisciplinary, non-drug program using acupuncture, remote physical rehab, and brain-health activities is being tested to see if it can improve quality of life for adults at least one year after heart, kidney, liver, or lung transplant.

  Recruiting The Mediterranean Institute for Transplantation and Advanced Specialized Therapies · Palermo, Palermo · NCT07870811

• Multimodal prospective approach to understand acute and chronic lung transplant rejection

  This project will see if blood tests, airway sampling, imaging, and genetic analyses can identify which adults who have had or are being evaluated for a lung transplant will develop antibody‑mediated rejection and later chronic graft dysfunction.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07516379

• Airway response to exercise after double lung transplant

  This study will see if short (5-minute) versus longer (15-minute) constant-work exercise causes different airway narrowing and breathlessness in people who have had a double lung transplant.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07035743

• Measuring breathing effort before and after removing the breathing tube

  This will test a new electrical impedance method to measure breathing effort in adults on ventilators as they try breathing on their own and after the breathing tube is removed.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07017608

• Cryo nerve block to improve recovery after bilateral lung transplant

  This pilot will test whether adding a cryo nerve block around the chest helps people with end-stage COPD recover better after a bilateral lung transplant.

  Recruiting University Hospital, Gasthuisberg · Leuven, Vlaams-Brabant · NCT06959056

• Using ECMO to support lung transplant patients with right heart failure from pulmonary hypertension

  This study is testing if a special heart-lung machine can help patients with severe right heart failure from pulmonary hypertension while they wait for a lung transplant.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06770023

• Registry for lung transplant outcomes using the OCS Lung System

  This study is tracking how well lung transplants work for patients who received donor lungs preserved with a new device called the OCS Lung System to see if it improves outcomes.

  Recruiting at 7 sites TransMedics · Phoenix, Arizona and 6 other locations · NCT06513091

• Using Belumosudil to prevent lung transplant complications

  This study is testing if a new drug called Belumosudil can help prevent lung transplant complications in high-risk patients who have signs of rejection or inflammation.

  Recruiting at 12 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · Los Angeles, California and 11 other locations · NCT06476132

• Research on improving outcomes for lung transplant donors and recipients

  This study is trying to see how different donor and medical practices affect the health of lung transplant patients and donors, while also looking for blood markers that might predict complications after the surgery.

  Recruiting at 19 sites Duke University · Los Angeles, California and 18 other locations · NCT06399302

• Research on improving outcomes for lung transplant donors and recipients

  This study is trying to see how different donor and medical practices affect the health of lung transplant patients and donors, while also looking for blood markers that might predict complications after the surgery.

  Recruiting at 19 sites Duke University · Los Angeles, California and 18 other locations · NCT06399302

• Using Tocilizumab to improve outcomes in lung transplant patients

  This study is testing if adding Tocilizumab to the usual treatment can help lung transplant patients have better health outcomes compared to those who get a placebo.

  Recruiting at 13 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · Phoenix, Arizona and 20 other locations · NCT06033196

• Latin dance program for lung transplant patients

  This study tests whether a 12-session Latin dance program can help lung transplant patients feel better by improving their balance, reducing anxiety and depression, and boosting their lung function.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05924113

• Kidney oxygen monitoring with near-infrared light during lung transplant surgery

  This project tests whether watching kidney oxygen levels with near-infrared light during lung transplant surgery can help predict which adults will develop postoperative acute kidney failure.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT05836922

• Monitoring CMV immunity in lung transplant patients

  This study is testing a new lab test to see how well lung transplant patients' immune systems respond to a virus, which could help doctors decide how long they need to take antiviral medication.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT05708755

• Registry for double lung transplants in patients with lung-limited cancers

  This study is collecting information on patients with lung-limited cancers who are getting double lung transplants to see how well the procedure works for them.

  Recruiting Northwestern University · Chicago, Illinois · NCT05671887

• Lung transplants from A2 donors to O recipients

  This study is testing if lung transplants from A2 blood type donors can safely help people with O blood type who are waiting for a transplant.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05581745

• Comparing off-pump lung transplantation to venoarterial ECMO lung transplantation

  This study is testing two different methods for lung transplantation to see which one leads to fewer problems with the new lungs after surgery.

  Recruiting at 9 sites Mayo Clinic · Los Angeles, California and 9 other locations · NCT05547698

• Cytokine filtration in lung transplantation

  This study is testing whether using a special device to filter out harmful substances during lung transplants can help patients have fewer complications and live longer.

  Recruiting Lund University Hospital · Lund, Skåne County · NCT05526950

• Health coaching for lung transplant candidates

  This study tests whether personalized health coaching can help people waiting for a lung transplant feel better and manage their health more effectively compared to standard care.

  Recruiting at 2 sites Mayo Clinic · Jacksonville, Florida and 2 other locations · NCT05426200

• Identifying biomarkers for lung transplant dysfunction

  This study is trying to find specific markers in the body that can help doctors understand and manage problems after lung transplants for patients at Foch Hospital.

  Recruiting Hopital Foch · Suresnes · NCT04837339

• Using long-acting tacrolimus for lung transplant patients

  This study is testing if a new long-acting version of tacrolimus can help lung transplant patients avoid complications and protect their kidneys better than traditional medications.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04469842

• Registry for thoracic disease specimens

  This study is collecting samples from patients with lung diseases like lung cancer to help researchers learn more about these conditions and find better treatments.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04118660

• Using a device to reduce reflux in lung transplant patients

  This study is testing whether the Reflux Band™ device can help lung transplant patients manage their acid reflux symptoms better.

  Recruiting University of Florida · Gainesville, Florida · NCT03886961

NIH-funded research (newest 40 of 49)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exercise-based frailty program for people awaiting lung transplants

  A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11550096

• Understanding why a lung transplant sometimes fails early and how to tailor treatment

  A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.

  NIH research Northwestern University · Chicago, United States · NIH-11429612

• Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab

  A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11416426

• Vaccination responses in lung transplant patients

  This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.

  NIH research Stanford University · Stanford, United States · NIH-11406132

• The Post-Lung Transplant Aging in Immune Cells in Donor Lungs

  This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.

  NIH research Duke University · Durham, United States · NIH-11403947

• Predictors of Lung Transplant Success and Costs

  This study looks at what pre-transplant patient factors and biology predict a smooth recovery and lower costs after lung transplant.

  NIH research Duke University · Durham, United States · NIH-11394471

• Lung Transplant Network Data Center coordinating multicenter research

  A national network is creating a shared data and biosample hub to support a large study of people who receive lung transplants.

  NIH research Duke University · Durham, United States · NIH-11394228

• Lung transplant recipients: exosome markers predicting early and intermediate graft problems

  This project looks at tiny particles from the immune system in people who have had a lung transplant to see if they can predict early graft problems and later lung dysfunction.

  NIH research University of Washington · Seattle, United States · NIH-11387623

• National coordination of lung transplant patient data and biosamples

  This effort collects detailed health information and repeated blood and tissue samples from people who get lung transplants to help researchers learn what affects early and long-term outcomes.

  NIH research Duke University · Durham, United States · NIH-11382478

• Spleen monocytes that drive early lung damage after transplant

  This work looks at whether monocytes released from the spleen trigger the inflammation that causes early lung injury in people after a lung transplant.

  NIH research Northwestern University · Chicago, United States · NIH-11377369

• Microfluidic test to measure chromatin fibers in lung transplant patients' BAL fluid

  A new, safer test using tiny fluid channels could help doctors detect early signs of lung transplant problems by examining fluid from the lungs.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11373856

• Optimizing Lung Transplant Benefit with Advanced Simulation

  A lung transplant grant using computer-based simulations to improve how organs are allocated to patients.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11373529

• A place-based approach to geographic disparities in lung transplant

  Aiming to understand how where people live affects lung transplant outcomes and to improve survival for transplant patients.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11364924

• Immuno-Metabolic Drivers of Chronic Rejection after Lung Transplant

  A doctor-researcher is studying why some lung transplant patients develop chronic rejection and what metabolic and immune signals cause this, with the goal of making BOS preventable or treatable.

  NIH research Washington University · Saint Louis, United States · NIH-11352598

• Lung Transplant: Tailored Ways to Prevent Rejection

  This NIH grant explores why lung transplants fail after surgery and looks for lung-specific ways to prevent rejection with targeted treatments.

  NIH research Washington University · Saint Louis, United States · NIH-11330429

• Health coaching for people waiting for a lung transplant

  Short, 30-minute phone coaching sessions aim to help adults with COPD who are on the lung transplant waiting list manage emotions and daily health tasks.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11326744

• How short telomeres affect immune health and outcomes after lung transplant

  This work looks at whether short telomeres change immune defenses, make viral infections worse, or alter rejection and recovery for people getting lung transplants, especially those with idiopathic pulmonary fibrosis.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11308303

• Cell therapies to help lung transplant patients accept new lungs without lifelong immune-suppressing drugs

  New bone marrow conditioning and regulatory T‑cell therapies aim to help people who receive lung transplants keep their new lungs long-term without chronic immunosuppression.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11285373

• Preparing adults with cystic fibrosis for lung transplant conversations and choices

  This project offers a web program called Take on Transplant to help adults with cystic fibrosis learn about lung transplant and feel ready to talk and decide.

  NIH research University of Washington · Seattle, United States · NIH-11262180

• Cell stress in the lung that may cause long-term transplant failure

  Looks at whether a prolonged cellular 'stress response' in the lung after transplant leads to scarring and long-term graft failure in people who have had lung transplants.

  NIH research Northwestern University · Chicago, United States · NIH-11252538

• Donor immune cells that cause early lung transplant and kidney injury

  This project looks for ways to stop donor immune cells that cause early lung transplant failure and harm other organs in people receiving lung transplants.

  NIH research Northwestern University · Chicago, United States · NIH-11249143

• Exercise program to reduce frailty in people awaiting lung transplant

  A tailored exercise and lifestyle program to help people who are frail while waiting for a lung transplant get stronger and more active.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11193900

• Exosome patterns in lung transplant recipients and early graft injury risk

  This project looks at tiny particles called exosomes in people who had lung transplants to identify patterns that signal early graft injury like primary graft dysfunction or acute lung allograft dysfunction.

  NIH research University of Washington · Seattle, United States · NIH-11170442

• Central coordination of data and biosamples for lung transplant patients

  This project will collect health information and blood/tissue samples from people who get lung transplants to help doctors learn how to prevent complications and improve long-term outcomes.

  NIH research Duke University · Durham, United States · NIH-11161562

• Vaccine responses in people with lung transplants

  This project looks at how well COVID-19 vaccines trigger immune protection in people who have had lung transplants.

  NIH research Stanford University · Stanford, United States · NIH-11158660

• Predictors of an ideal recovery after lung transplant

  This project looks at clinical signs and laboratory measures that may help predict which adults will have a smooth, complication-free recovery after a lung transplant.

  NIH research Duke University · Durham, United States · NIH-11146508

• Network to improve long-term outcomes after lung transplant

  This project is testing whether adding an oral drug called belumosudil to standard post-transplant medicines can lower lung inflammation and help lung transplant recipients keep their new lungs working longer.

  NIH research Duke University · Durham, United States · NIH-11144415

• Clazakizumab to lower immune damage after lung transplant

  This project gives the drug clazakizumab to people who have had a lung transplant to try to reduce harmful inflammation and prevent rejection.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11120969

• Helping Lung Transplants Last Longer

  This research looks for new ways to help the body accept a transplanted lung and prevent rejection, aiming for better long-term success for patients.

  NIH research Washington University · Saint Louis, United States · NIH-11112098

• Detecting early lung transplant rejection with advanced imaging

  This project uses a special imaging technique to find early signs of lung rejection in people who have had a lung transplant.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11109637

• Understanding how where you live affects lung transplant outcomes

  This project explores how a patient's living environment might affect their lung health and survival after a lung transplant.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11109417

• Understanding Long-Term Outcomes After Lung Transplant

  This project continues to follow patients who have received lung transplants to better understand their health over many years.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11099858

• Health coaching to improve outcomes for lung transplant candidates

  This study is all about helping people waiting for a lung transplant feel better and manage their health through friendly phone coaching, so they can be more prepared for their transplant and enjoy a better quality of life.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11086125

• Investigating how telomeres affect immunity and outcomes in lung transplant recipients

  This study is looking at lung transplant patients with idiopathic pulmonary fibrosis to see how certain gene changes affect their immune system and the chances of their new lungs being accepted, with the goal of finding ways to help them live healthier, longer lives after their transplant.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11084363

• Understanding how iron overload in lung transplant patients affects their immune response to fungal infections.

  This study looks at how too much iron in the body can make it harder for lung transplant patients to fight off fungal infections, using mice to understand how this happens and hoping to find ways to help improve their health.

  NIH research Stanford University · Stanford, United States · NIH-11061050

• Improving lung transplant acceptance through cellular therapies

  This study is looking for new ways to help people who have received lung transplants accept their new lungs without needing to take medication for the rest of their lives, by using safe methods to help their bodies recognize the transplant as part of themselves.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11035230

• Understanding how stress responses affect lung transplant outcomes

  This study is looking at how stress in the body affects lung transplants and aims to find ways to improve the health of transplanted lungs by understanding how certain cells behave, so it’s for people who have had a lung transplant and want to ensure their new lungs stay healthy.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11024748

• Understanding patient priorities for quality of life in lung transplant decisions

  This study is looking at how people with severe lung disease and their caregivers think about what matters most to them when deciding whether to get a lung transplant, so they can create a helpful tool that makes it easier for them to understand how the transplant might affect their quality of life.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11014341

• Understanding how certain immune cells affect lung transplant success and organ injury.

  This study is looking at how certain immune cells from donors might cause problems after lung transplants, like lung and kidney injuries, and aims to find new ways to help lung transplant patients recover better.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11013351

• Helping cystic fibrosis patients prepare for lung transplant discussions

  This study is all about helping people with cystic fibrosis understand their options for lung transplants better, especially those who might face challenges getting referred for one, by using a friendly online resource called 'Take on Transplant' that shares helpful information and personal stories to make the process

  NIH research University of Washington · Seattle, United States · NIH-11009036

Related topics

Quick answers

How many Lung Transplant clinical trials are recruiting right now?

23, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (15 trials), Canada (5 trials), France (2 trials), Belgium (2 trials), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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