Condition

Rejection clinical trials and research

• 10Clinical trials
• 98NIH research projects
• 1New in 30 days
• 8Countries

Newest Rejection clinical trials

All recruiting trials (10)

• Immune biomarkers to predict complications after liver transplantation

  This study tests immune biomarkers in adults after liver transplant to see if changes in markers relate to infections, rejection, or viral reactivation within the first year.

  Recruiting at 3 sites Hospital Italiano de Buenos Aires · Pilar, Buenos Aires and 2 other locations · NCT07875595

• Non-invasive test to predict early heart rejection in pediatric transplant patients

  This study tests non-invasive heart tests like cardiac MRI and blood markers to see if they can detect rejection in kids after heart transplant, potentially reducing the need for invasive biopsies.

  Recruiting at 22 sites Vanderbilt University Medical Center · Little Rock, Arkansas and 21 other locations · NCT07770659

• Multimodal prospective approach to understand acute and chronic lung transplant rejection

  This project will see if blood tests, airway sampling, imaging, and genetic analyses can identify which adults who have had or are being evaluated for a lung transplant will develop antibody‑mediated rejection and later chronic graft dysfunction.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07516379

• TTV-guided long-term immunosuppression in kidney transplant recipients

  This trial tests whether checking Torque Teno Virus (TTV) levels every three months starting in the second year after transplant can help tailor immunosuppressive drugs for adult kidney transplant recipients to reduce infections, rejection, and cancer.

  Recruiting at 2 sites Hospices Civils de Lyon · Bordeaux (France) and 3 other locations · NCT06829719

• Using gene analysis to improve diagnosis of liver transplant rejection

  This study is testing whether analyzing specific genes in liver transplant patients can help doctors diagnose rejection faster and more accurately.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06734013

• Analyzing liver grafts to predict transplant outcomes

  This study is testing if certain markers in liver grafts can help predict how well the transplant will work for patients receiving the liver.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06717542

• Finding the right steroid dose for acute T cell rejection after kidney or kidney–pancreas transplant

  This trial will test whether lower doses of steroids work as well as higher doses to treat acute T cell–mediated rejection in people who have had a kidney or simultaneous kidney–pancreas transplant.

  Recruiting at 2 sites Phase 3 University of Sydney · Lambton, New South Wales and 29 other locations · NCT06474273

• Finding the right steroid dose for acute T cell rejection after kidney or kidney–pancreas transplant

  This trial will test whether lower doses of steroids work as well as higher doses to treat acute T cell–mediated rejection in people who have had a kidney or simultaneous kidney–pancreas transplant.

  Recruiting at 2 sites Phase 3 University of Sydney · Lambton, New South Wales and 29 other locations · NCT06474273

• Detecting kidney DNA in transplant patients with potential rejection

  This study is testing a new way to check for kidney transplant rejection by looking at DNA in the blood of patients instead of doing a traditional biopsy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 2 other locations · NCT06351488

• Investigating white blood cells to develop new therapies for autoimmune diseases

  This study is trying to learn more about white blood cells from volunteers to help create new treatments for autoimmune diseases.

  Recruiting Quell Therapeutics Limited · London · NCT04838171

NIH-funded research (newest 40 of 98)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Injecting immune-boosting medicine into melanoma tumors to help the immune system reject them

  This gives an immune-boosting drug directly into melanoma tumors in pet dogs to help their T cells find and destroy the cancer.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-11520231

• Immunological mechanisms behind treatment-resistant kidney transplant rejection

  This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11449432

• Targeting graft T cells to reduce transplant rejection

  A patient-facing study exploring how immune cells within transplanted organs drive rejection and how we might reduce trouble for people who need organ transplants.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11449411

• Engineered kidney 'chip' to study antibody-driven rejection and how the body adapts

  A kidney-rejection research grant is developing a miniaturized, human cell–based chip to model how antibodies cause rejection and how kidneys may adapt.

  NIH research Duke University · Durham, United States · NIH-11439084

• Social media, mood, and teens: how the menstrual cycle affects rejection feelings and online experiences

  Teenagers using social media may feel stronger negative reactions to online feedback, especially around certain times in their menstrual cycle, which could relate to mood and depression.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11438547

• Understanding how BK virus links infection to kidney transplant rejection

  This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11436797

• Phase 1 trial of siltuximab for antibody-mediated rejection after lung transplant

  A early-stage study tests whether siltuximab can help people who have antibody-mediated rejection after lung transplantation.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11419647

• Biomarkers to tailor liver transplant immunosuppression

  A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.

  NIH research Northwestern University · Chicago, United States · NIH-11412569

• Targeting B cells to treat antibody-driven rejection in organ transplants

  A study to see if removing B cells and disrupting their signaling can help treat antibody-mediated rejection in people who have had organ transplants.

  NIH research Duke University · Durham, United States · NIH-11408646

• Targeted delivery of immune-suppressing agents to the lung graft to prevent rejection

  A study at Northwestern University will test a new, targeted approach to prevent lung transplant rejection by delivering immune-suppressing drugs directly to the graft while blocking early signals that trigger rejection.

  NIH research Northwestern University · Chicago, United States · NIH-11401866

• Siltuximab for antibody-mediated rejection after lung transplant

  This trial gives siltuximab to people with antibody-mediated rejection after a lung transplant to try to control the immune response harming the new lung.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11394141

• Using blood biomarkers to guide immunosuppression after liver transplant

  This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.

  NIH research Northwestern University · Chicago, United States · NIH-11392822

• Major immune-friendly stem cell transplants to prevent graft rejection

  A patient-facing approach to safer stem cell transplants by using gene editing to reduce immune rejection and improve chances of engraftment.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11392480

• Post-transcriptional regulation of gene expression by microRNAs in kidney transplant rejection

  A kidney transplant study looks at small genetic helpers called microRNAs and how they control gene activity during antibody-driven rejection of the transplant.

  NIH research Tufts University Boston · Boston, United States · NIH-11391268

• Hyperpolarized gas MRI to detect and guide care for lung transplant rejection

  A new imaging tool using specialized MRI scans aims to spot lung transplant rejection early, so doctors can tailor treatment for patients with transplanted lungs.

  NIH research University of Virginia · Charlottesville, United States · NIH-11387572

• Rejection sensitivity and puberty: how social media affects mental health in early-adolescent girls

  This project follows a group of 250 girls aged 10–11 to see how online rejection experiences and puberty timing relate to changes in mood and mental health over three years.

  NIH research Washington University · Saint Louis, United States · NIH-11385263

• Understanding rejection sensitivity and mental health in LGBTQ+ teens

  A long-term study follows LGBTQ+ adolescents to see how worries about rejection affect their mood and mental well-being.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11381580

• Vascularized liver-heart on-a-chip to study antibody-mediated rejection and tolerance

  A scientist-led project will use a chip-based, vascularized liver model to study how antibodies contribute to transplant rejection and how tolerance might be achieved in organ transplants.

  NIH research Terasaki Institute for Biomedical Innovation · Woodland Hills, UNITED STATES · NIH-11377354

• Targeting YAP and TAZ with statins to prevent transplant rejection from donor antibodies

  A study to see if statins can block specific gene regulators (YAP and TAZ) to protect transplanted organs from rejection caused by donor antibodies.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11374827

• Role of HLA-E restricted CD8 regulatory T cells in kidney transplant rejection

  A study in people with kidney transplants to understand how a special group of immune cells (CD8 regulatory T cells) control antibody-driven rejection and could lead to new ways to protect grafts.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11372858

• Personalized breast cancer screening: using your own risk to guide when and how often to get mammograms

  A study from the University of Colorado Denver aims to help women make smarter, personalized decisions about when to start and how often to get mammograms based on their own breast cancer risk.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11370886

• Predicting acute rejection in children after heart transplant

  A study to improve how doctors predict if a child who has had a heart transplant will have acute rejection using noninvasive blood markers and advanced heart MRI analysis.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11364137

• A new biologic medicine to help prevent organ rejection

  This project develops a single engineered protein designed to stop transplant rejection in people by blocking harmful immune signals and boosting protective immune cells.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11354547

• Modeling how fibrous and bile duct cells interact in kids after liver transplant trouble

  A study in children who have liver transplants looks at how certain bile duct cells and immune cells interact to cause a common rejection problem so we can find new ways to protect the liver.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11353744

• Immuno-Metabolic Drivers of Chronic Rejection after Lung Transplant

  A doctor-researcher is studying why some lung transplant patients develop chronic rejection and what metabolic and immune signals cause this, with the goal of making BOS preventable or treatable.

  NIH research Washington University · Saint Louis, United States · NIH-11352598

• Role of plasma cells in chronic rejection after lung transplantation

  This research looks at how certain immune cells called plasma cells may drive chronic rejection in people who have had lung transplants and how this could lead to new ways to protect the transplant.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11346016

• How blood-flow injury at transplant affects lung transplant rejection

  This project tests whether reducing early blood-flow injury and calming the immediate immune reaction after a lung transplant helps prevent rejection and improve outcomes for lung transplant recipients.

  NIH research Washington University · Saint Louis, United States · NIH-11334335

• Non-invasive infection detection after lung transplant

  A non-invasive blood test using phage-based signals could help doctors detect lung infections early in people who have had a lung transplant.

  NIH research Stanford University · Stanford, United States · NIH-11333348

• Kidney transplants from HIV-positive donors: impact on rejection and long-term outcomes

  This study will compare kidney transplant outcomes for HIV-positive donor to HIV-positive recipient transplants versus HIV-negative donor transplants in people living with HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11324988

• Preventing antibody rejection and infections after transplant in older adults

  This project is trying to reduce antibody-driven rejection while keeping antiviral defenses strong in people aged 65 and older who receive a kidney or heart transplant.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11321236

• Existing medicines for antibody-related kidney transplant rejection

  This project looks for already-approved drugs or drug combinations that could calm harmful antibodies that attack kidney transplants.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11321234

• How the protein ID3 controls donor T cells that cause GVHD and fight leukemia

  Researchers are looking at whether changing the activity of a protein called ID3 in donor T cells can lower graft-versus-host disease while keeping those cells able to attack leukemia after a stem cell transplant.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11317224

• Precision diagnostics to predict treatment resistance in kidney transplant rejection

  A small, patient-focused test using a kidney biopsy and gene patterns to help doctors decide the best immune-suppression plan at the moment a transplant shows rejection.

  NIH research Nephropathology Associates · Little Rock, United States · NIH-11315213

• Long-term antibody damage to kidney transplants

  This work looks at how very high levels of antibodies that target a donor kidney can cause either fast rejection or slow scarring in people with kidney transplants.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11301834

• Stopping antibody rejection of pig kidney transplants for sensitized patients

  New approaches aim to stop antibody attacks on pig kidney transplants for patients who already have anti-donor antibodies.

  NIH research Duke University · Durham, United States · NIH-11284100

• How donor HLA antibodies trigger blood-vessel injury after transplant

  Learning how antibodies against donor HLA make the graft's blood vessels activate and draw in immune cells in transplant patients.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11258860

• Personalized transplant rejection diagnostic using advanced RNA and immune profiling

  A new test uses advanced RNA and immune-cell analysis to help doctors choose personalized anti-rejection therapy for kidney transplant patients.

  NIH research Datirium, LLC · Cincinnati, UNITED STATES · NIH-11254890

• Antibodies to chemically modified proteins that may harm kidney transplants

  This project looks at whether certain antibodies that bind chemically changed proteins are linked to rejection in people who have had a kidney transplant.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11250026

• Investigating immune responses in kidney transplant rejection

  This study is looking at how certain immune cells in your body might affect the success of kidney transplants, especially if you've had previous infections, to help find better treatments that could reduce the need for long-term medication after surgery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11248001

• VisR ultrasound to monitor antibody-driven rejection after a kidney transplant

  A new ultrasound method called VisR is being used to look for antibody-related rejection in people who have received a kidney transplant.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11237604

Related topics

Quick answers

How many Rejection clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in Italy (2 trials), Australia (2 trials), Canada (2 trials), New Zealand (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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