Understanding how certain immune cells affect lung transplant success and organ injury.
Donor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgery
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11013351
This study is looking at how certain immune cells from donors might cause problems after lung transplants, like lung and kidney injuries, and aims to find new ways to help lung transplant patients recover better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11013351 on ClinicalTrials.gov |
What this research studies
This research investigates the role of donor nonclassical monocytes in causing complications after lung transplantation, particularly primary graft dysfunction (PGD) and injury to other organs like the kidneys. By studying how these immune cells interact with classical monocytes in the transplant recipient, the research aims to uncover the mechanisms that lead to organ damage. The project will involve laboratory experiments to identify pathways that could be targeted for new treatments, ultimately aiming to improve the outcomes for lung transplant patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing lung transplantation or those who have experienced complications related to lung transplants.
Not a fit: Patients who are not candidates for lung transplantation or those with unrelated health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the success of lung transplants and reduce complications in other organs.
How similar studies have performed: Previous research has shown promise in understanding immune cell interactions in transplant settings, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHARAT, ANKIT — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: BHARAT, ANKIT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury