Helping Lung Transplants Last Longer
Official title: Pathways Regulating Lung Transplant Tolerance
Funded at Washington University · NIH-11112098 · Data updated 2026-11-12
This research looks for new ways to help the body accept a transplanted lung and prevent rejection, aiming for better long-term success for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 12, 2015 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,500,000 |
| NIH project number | 2P01AI116501-11 |
| Project ID | NIH-11112098 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is ultimately for patients who have received or will receive a lung transplant.
✕Less likely to help
Patients not undergoing or considering lung transplantation would not directly benefit from this specific research.
What this research studies
Lung transplants are a life-saving option, but many patients face challenges with their new lungs lasting a long time. This research believes that current anti-rejection medicines might not be perfectly suited for the unique needs of lung transplants. We are working to uncover the specific ways the body's immune system interacts with a transplanted lung. By understanding these interactions, we hope to find new targets for medicines that can prevent rejection and help the body accept the new lung more effectively. This work uses advanced models to study these processes, with the ultimate goal of improving outcomes for people who receive lung transplants.
Why it matters
Potential benefit: If successful, this work could lead to new, more effective treatments that help transplanted lungs last longer and improve the quality of life for patients.
How similar studies have gone: This research builds on existing knowledge about lung transplantation and aims to discover novel pathways for preventing rejection.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Kreisel, Daniel — Washington University
- Study coordinator: Kreisel, Daniel
Related research
Other NIH-funded projects on the same topics.
-
Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
-
Understanding why a lung transplant sometimes fails early and how to tailor treatment
A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.
-
Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab
A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.
-
Vaccination responses in lung transplant patients
This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.
-
The Post-Lung Transplant Aging in Immune Cells in Donor Lungs
This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.
-
Predictors of Lung Transplant Success and Costs
This study looks at what pre-transplant patient factors and biology predict a smooth recovery and lower costs after lung transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.