Condition

GERD clinical trials and research

• 20Clinical trials
• 10NIH research projects
• 13Countries

Newest GERD clinical trials

All recruiting trials (20)

• Thread-Embedding Acupuncture plus a Proton Pump Inhibitor for GERD

  This study tests whether adding thread-embedding acupuncture to standard omeprazole treatment helps people with GERD who have a traditional Liver-Stomach constraint-heat pattern.

  Recruiting University of Science Ho Chi Minh City · Ho Chi Minh City · NCT07797959

• Transoral incisionless fundoplication (TIF) for GERD in Asian adults

  This tests whether a less-invasive transoral incisionless fundoplication (TIF) procedure can reduce reflux symptoms in Asian adults who continue to have GERD despite daily PPI treatment.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT07556289

• Diaphragm training for GERD symptoms

  This study will test whether diaphragm-focused breathing exercises or using a volume-based incentive spirometer can help people with GERD have fewer reflux episodes and better symptoms.

  Recruiting Changhua Christian Hospital · Changhua, Changhua County · NCT07544433

• A registry for adults with esophageal movement and reflux problems.

  This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT07506746

• Comparing Trimedat 76.95 mg orally disintegrating tablets with Trimedat 100 mg tablets in healthy adults

  This will test if Trimedat 76.95 mg dissolving tablets work the same and are as safe as Trimedat 100 mg tablets when taken fasting by healthy adults.

  Recruiting Phase 1 Valenta Pharm JSC · Saint Petersburg · NCT07421011

• Nighttime heartburn treatment for people with erosive reflux disease

  This study will try zastaprazan 20 mg versus esomeprazole 40 mg to see if either reduces nighttime heartburn in adults with erosive reflux disease.

  Recruiting at 10 sites Phase 4 Incheon St.Mary's Hospital · Ansan and 9 other locations · NCT07268820

• Using a mucosal impedance device to help diagnose chronic esophageal problems

  This test tries a mucosal impedance device during upper endoscopy to see if it helps diagnose people with chronic reflux (GERD) or eosinophilic esophagitis.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07227506

• Vonaprazan versus Esomeprazole for healing moderate-to-severe reflux esophagitis after POEM

  This trial tests whether vonaprazan or esomeprazole better heals LA grade B or higher reflux esophagitis in adults who developed it after POEM.

  Recruiting Asian Institute of Gastroenterology, India · Hyderabad, Telangana · NCT06955520

• Comparing two doses of vonoprazan and esomeprazole for healing moderate-to-severe reflux esophagitis in 8 weeks

  This study will test whether taking vonoprazan (10 mg or 20 mg) or esomeprazole 40 mg once daily heals moderate-to-severe reflux esophagitis after 8 weeks.

  Recruiting Asian Institute of Gastroenterology, India · Hyderabad, Telangana · NCT06953986

• Comparing famotidine and antacids for treating dyspepsia

  This study is testing whether an IV medication called famotidine works better than an antacid for quickly relieving stomach pain in people with dyspepsia who come to the emergency room.

  Recruiting Phase 4 Stony Brook University · Stony Brook, New York · NCT06241183

• Evaluating pH-impedance tracings for GERD classification

  This study is testing how pH-impedance tracings can help better classify gastroesophageal reflux disease (GERD) in patients by looking at why some reflux episodes are ignored and considering factors like symptom severity and medication use.

  Recruiting at 3 sites Universitair Ziekenhuis Brussel · Anderlecht and 2 other locations · NCT06084572

• Comparing mesh and sutures for paraesophageal hernia repair

  This study is testing whether using a special mesh or stitches works better to prevent paraesophageal hernias from coming back after surgery for people who need this repair.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05974722

• Understanding how to prevent pharyngeal reflux in GERD patients

  This study is trying to understand how the muscles in the throat work in people with GERD to see if they can help prevent reflux from reaching the throat.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05696184

• Investigating the effects of linaprazan glurate on the body and heart

  This study is testing a new medication called linaprazan glurate to see how it affects the body and heart in healthy people.

  Recruiting Phase 1 Cinclus Pharma Holding AB · Uppsala · NCT05469854

• Magnetic bariatric revisional surgery for weight loss and GERD resolution

  This study tests if a new type of weight loss surgery using magnets can help people with obesity and acid reflux feel better after previous weight loss surgeries.

  Recruiting Unidad Internacional de Cirugia Bariatrica y Metabolica · Maracaibo, Zulia · NCT04945304

• Surgery to reduce GERD in patients revising from sleeve gastrectomy to gastric bypass

  This study is testing whether a specific type of surgery can help adults who had sleeve gastrectomy and now suffer from GERD feel better after switching to gastric bypass.

  Recruiting Baylor Research Institute · Dallas, Texas · NCT04901429

• Using domperidone to help young people with severe stomach issues

  This study is testing if the medication domperidone can help young people aged 12 to 21 with severe stomach problems that haven't improved with other treatments.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT04699591

• Evaluating stomach and esophagus changes after gastric bypass surgery

  This study is testing how gastric bypass surgery affects the stomach and esophagus in people with obesity who haven't lost weight through other methods.

  Recruiting Spital Limmattal Schlieren · Schlieren, Canton of Zurich · NCT04422405

• Investigating the impact of diet on gastroesophageal reflux disease symptoms

  This study is testing how sticking to certain diets for a long time can affect symptoms in people with gastroesophageal reflux disease (GERD).

  Recruiting Federal State Budgetary Scientific Institution · Moscow · NCT04255693

• Using a device to reduce reflux in lung transplant patients

  This study is testing whether the Reflux Band™ device can help lung transplant patients manage their acid reflux symptoms better.

  Recruiting University of Florida · Gainesville, Florida · NCT03886961

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Omega PF device: a new, easier surgical option for drug-resistant GERD

  A new medical device aims to replace complicated GERD surgery with a simpler, safer procedure for people whose reflux isn’t controlled by medicines.

  NIH research Aplos Medical INC · Eden Prairie, United States · NIH-11403848

• Pathophysiology-based GERD management in NICU infants guided by pH-impedance testing

  A NICU randomized trial tests how newborns with suspected GERD respond to standard care, acid-suppressing therapy, or thicker feeds guided by objective pH-impedance tests.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11399922

• A safer sleeve surgery to reduce reflux after weight-loss surgery

  A new version of vertical sleeve gastrectomy is being tested to lower the chance of acid reflux and reduce the risk of Barrett’s esophagus in people considering or having weight-loss surgery.

  NIH research University of California-Irvine · Irvine, United States · NIH-11382919

• Reducing over-alertness and stress responses that worsen acid reflux

  This work tests whether calming excessive vigilance and automatic stress reactions can help adults with GERD have fewer symptoms and better quality of life.

  NIH research Northwestern University · Chicago, United States · NIH-11377230

• Repurposing Fosamprenavir to Help Older Adults with GERD

  A clinician-scientist team is testing a repurposed HIV drug, fosamprenavir, combined with sodium alginate, to relieve persistent GERD symptoms in older adults who don’t respond well to standard acid-suppressing therapy.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11268079

• Surgical technique to reduce acid reflux after sleeve gastrectomy

  This trial tests a modified sleeve gastrectomy designed to lower new or worsening acid reflux in adults with obesity who are having bariatric surgery.

  NIH research University of California-Irvine · Irvine, United States · NIH-11195060

• Using objective testing to guide reflux care for newborns in the NICU

  This project compares three approaches—natural maturation, acid-suppressing medicine (PPI), and thickened feeds with added rice—to help NICU infants under six months who have reflux confirmed by 24-hour pH-impedance testing.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11167841

• New surgical method to reduce acid reflux after weight loss surgery

  This study is testing a new type of weight loss surgery that aims to help people with obesity who also struggle with acid reflux, to see if it can reduce their reflux symptoms while helping them lose weight.

  NIH research University of California-Irvine · Irvine, United States · NIH-11050836

• Investigating the best treatments for acid reflux in premature infants in the NICU

  This study is looking to find better ways to diagnose and treat gastroesophageal reflux disease (GERD) in high-risk newborns in the NICU by using special tests and comparing different treatment options to help these little ones feel better.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10927443

• A new device to treat gastroesophageal reflux disease (GERD)

  This study is testing a new, easy-to-use device called the Ω-Cuff that helps people with gastroesophageal reflux disease (GERD) by reducing acid reflux without surgery that changes the esophagus, so you can feel better and rely less on medications.

  NIH research Aplos Medical INC · Eden Prairie, United States · NIH-10634514

Related topics

Quick answers

How many GERD clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (7 trials), Russia (2 trials), India (2 trials), South Korea (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →