Predictors of an ideal recovery after lung transplant
Official title: Clinical and Biological Factors Predicting Lung Transplant Textbook Outcomes (U01)
Funded at Duke University · NIH-11146508 · Data updated 2026-11-12
This project looks at clinical signs and laboratory measures that may help predict which adults will have a smooth, complication-free recovery after a lung transplant.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $392,751 |
| NIH project number | 5U01HL163300-04 |
| Project ID | NIH-11146508 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) who are listed for or undergoing lung transplantation at the participating transplant centers or similar programs are the most relevant candidates.
✕Less likely to help
Children, people not being considered for lung transplant, or patients cared for entirely outside participating centers are unlikely to directly benefit from participation in this project.
What this research studies
Researchers at four major U.S. transplant centers will combine medical records and lab tests from adults undergoing lung transplantation to find factors linked to a “textbook outcome” — an early recovery without major complications. The team will compare pre-transplant clinical characteristics and blood-based measures of biological aging across patients and centers. They will link those clinical and biological data to early post-operative outcomes such as graft function, kidney injury, and infection. The goal is to find reproducible predictors that could guide decision-making and post-transplant care.
Why it matters
Potential benefit: If successful, this work could help doctors identify patients at higher risk for complications and tailor care to improve the chances of a smoother recovery after lung transplant.
How similar studies have gone: Earlier single-center and registry analyses defined the 'textbook outcome' concept and linked it to survival and cost, but combining clinical predictors with measures of biological aging across multiple centers is a newer approach.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Snyder, Laurie D — Duke University
- Study coordinator: Snyder, Laurie D
Related research
Other NIH-funded projects on the same topics.
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Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
-
Understanding why a lung transplant sometimes fails early and how to tailor treatment
A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.
-
Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab
A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.
-
Vaccination responses in lung transplant patients
This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.
-
The Post-Lung Transplant Aging in Immune Cells in Donor Lungs
This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.
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Predictors of Lung Transplant Success and Costs
This study looks at what pre-transplant patient factors and biology predict a smooth recovery and lower costs after lung transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.