Predictors of an ideal recovery after lung transplant
Clinical and Biological Factors Predicting Lung Transplant Textbook Outcomes (U01)
This project looks at clinical signs and laboratory measures that may help predict which adults will have a smooth, complication-free recovery after a lung transplant.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11146508 on NIH RePORTER |
What this research studies
Researchers at four major U.S. transplant centers will combine medical records and lab tests from adults undergoing lung transplantation to find factors linked to a “textbook outcome” — an early recovery without major complications. The team will compare pre-transplant clinical characteristics and blood-based measures of biological aging across patients and centers. They will link those clinical and biological data to early post-operative outcomes such as graft function, kidney injury, and infection. The goal is to find reproducible predictors that could guide decision-making and post-transplant care.
Who could benefit from this research
Good fit: Adults (21+) who are listed for or undergoing lung transplantation at the participating transplant centers or similar programs are the most relevant candidates.
Not a fit: Children, people not being considered for lung transplant, or patients cared for entirely outside participating centers are unlikely to directly benefit from participation in this project.
Why it matters
Potential benefit: If successful, this work could help doctors identify patients at higher risk for complications and tailor care to improve the chances of a smoother recovery after lung transplant.
How similar studies have performed: Earlier single-center and registry analyses defined the 'textbook outcome' concept and linked it to survival and cost, but combining clinical predictors with measures of biological aging across multiple centers is a newer approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Snyder, Laurie D — Duke University
- Study coordinator: Snyder, Laurie D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.